PMID- 28689725
OWN - NLM
STAT- MEDLINE
DCOM- 20180308
LR  - 20181202
IS  - 0306-4565 (Print)
IS  - 0306-4565 (Linking)
VI  - 68
IP  - Pt A
DP  - 2017 Aug
TI  - Phylogenetic analysis of the allometry of metabolic rate and mitochondrial basal 
      proton leak.
PG  - 83-88
LID - S0306-4565(16)30294-7 [pii]
LID - 10.1016/j.jtherbio.2017.01.013 [doi]
AB  - The mitochondrial basal proton leak (MBPL) significantly contributes to high body 
      temperatures (T(b)) and basal metabolic rates (BMR) in endotherms. In endotherms 
      at a given body mass (M), liver MBPL is higher than in ectotherms, supporting the 
      notion that MBPL may partly explain the evolutionary increase in metabolic rate 
      (MR), fostering endothermy. Here, we re-addressed this assumption by performing a 
      phylogenetic analysis comparing all available liver MBPL data for ecto- and 
      endotherms. While MBPL within endotherms negatively scales with M and BMR as 
      shown previously, MBPL of ectotherms does not scale allometrically with M. 
      Phylogenetic analysis reveals that this result is confounded by a positive 
      scaling coefficient for MBPL with M for reptiles. Strikingly, the reptilian MBPL 
      reaches endothermic levels above a body mass of 6.6kg. Thus, phylogenetic scaling 
      of MBPL supports previous claims of endotherm-like physiological characteristics 
      in large reptiles. It appears that diversification of ancestral ectothermic 
      tetrapods to a body mass of at least 6kg may have been required to reach a MBPL 
      that is beneficial for sustained high body temperatures. Novel MBPL data for the 
      lesser hedgehog tenrec, a protoendothermic eutherian that displays reptile-like 
      thermoregulatory patterns, fall within the endo- and ectothermic allometric 
      regressions. Finally, we add additional evidence that within endotherms, 
      phylogenetic differences in MR do not correlate with MBPL. Collectively, these 
      data suggest that MBPL does not universally scale with metabolic rate in ecto- or 
      endotherms and that an increasing MBPL with M may have played an important 
      physiological role in the evolutionary history of reptilian thermoregulation.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Polymeropoulos, Elias T
AU  - Polymeropoulos ET
AD  - Menzies Institute for Medical Research, University of Tasmania, 7001 Hobart, 
      Australia. Electronic address: eliasp@utas.edu.au.
FAU - Oelkrug, R
AU  - Oelkrug R
AD  - Center of Brain, Behaviour and Metabolism, University of Lubeck, 23562 Lubeck, 
      Germany.
FAU - White, C R
AU  - White CR
AD  - Centre for Geometric Biology, School of Biological Sciences, Monash University, 
      3800 Melbourne, Australia.
FAU - Jastroch, M
AU  - Jastroch M
AD  - Institute for Diabetes and Obesity, Helmholtz Zentrum, 85764 Munich, Germany; 
      Department of Animal Physiology, Faculty of Biology, Philipps University of 
      Marburg, D-35032 Marburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170126
PL  - England
TA  - J Therm Biol
JT  - Journal of thermal biology
JID - 7600115
RN  - 0 (Protons)
SB  - IM
MH  - Animals
MH  - *Basal Metabolism
MH  - Biological Evolution
MH  - Mitochondria/physiology
MH  - *Phylogeny
MH  - Protons
OTO - NOTNLM
OT  - Allometry
OT  - Metabolic rate
OT  - Mitochondrial proton leak
OT  - Phylogeny
OT  - Scaling
EDAT- 2017/07/12 06:00
MHDA- 2018/03/09 06:00
CRDT- 2017/07/11 06:00
PHST- 2016/09/28 00:00 [received]
PHST- 2017/01/24 00:00 [revised]
PHST- 2017/01/25 00:00 [accepted]
PHST- 2017/07/11 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/03/09 06:00 [medline]
AID - S0306-4565(16)30294-7 [pii]
AID - 10.1016/j.jtherbio.2017.01.013 [doi]
PST - ppublish
SO  - J Therm Biol. 2017 Aug;68(Pt A):83-88. doi: 10.1016/j.jtherbio.2017.01.013. Epub 
      2017 Jan 26.