PMID- 28692122
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20171019
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 3
DP  - 2017 Jul 6
TI  - Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) 
      gene in house dust mite-sensitive allergic rhinitis patients in Thailand.
LID - 10.4238/gmr16039641 [doi]
AB  - Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, 
      which is naturally triggered by aeroallergens. House dust mites (HDM) are the 
      most common inhalant allergens. Interleukin-18 (IL-18) has been established as an 
      essential cytokine that can activate the generation of IgE. This randomized 
      controlled study aimed to identify the possible relationship of the genetic 
      variations in the IL-18 gene with AR in mite-sensitive Thai patients. Study 
      subjects consisted of 150 AR patients and 50 normal participants. Genomic DNA of 
      30 randomized AR patients and 30 randomized controls were screened by sequencing 
      for the selection of candidate single nucleotide polymorphisms (SNPs), and 
      further analyzed by polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) assay for all subjects. The following five SNPs were 
      detected in the IL-18 gene: -656 G/T, -607 C/A, and -137 G/C in promoter 1 and 
      -920 C/T and -373 C/G in promoter 2. The results showed that -656 G/T and -607 
      C/A SNPs were significantly correlated with IgE levels specific to 
      Dermatophagoides pteronyssinus (Der p) allergen (P = 0.045 and P = 0.045, 
      respectively), and significant differences were observed in the genotype 
      distribution of AR patients when compared with controls [P = 0.044 and P = 0.044, 
      respectively; odds ratios (ORs): 1.941 (95%CI, 1.014-3.715) and 1.941 (95%CI, 
      1.014-3.715), respectively]. Our findings indicate that the IL-18 alleles, -656T 
      (rs1946519) and -607A (rs1946518), might be associated with the higher production 
      of Der p allergen-specific IgE in mite-sensitive AR patients.
FAU - Tungtrongchitr, A
AU  - Tungtrongchitr A
AD  - Department of Parasitology, Faculty of Medicine, Siriraj Hospital, , , Thailand 
      anchalee.tun@mahidol.ac.th.
FAU - Jumpasri, J
AU  - Jumpasri J
AD  - Graduate Program in Microbiology, Department of Microbiology, Faculty of 
      Medicine, Siriraj Hospital, , , Thailand.
FAU - Sookrung, N
AU  - Sookrung N
AD  - Office for Research and Development, Faculty of Medicine, Siriraj Hospital, , , 
      Thailand.
FAU - Visitsunthorn, N
AU  - Visitsunthorn N
AD  - Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, , , Thailand.
FAU - Tantilipikorn, P
AU  - Tantilipikorn P
AD  - Department of Otolaryngology, Faculty of Medicine, Siriraj Hospital, , , 
      Thailand.
FAU - Piboonpocanan, O
AU  - Piboonpocanan O
AD  - Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, , , Thailand.
FAU - Indrawattana, N
AU  - Indrawattana N
AD  - Department of Microbiology and Immunology, Faculty of Tropical Medicine, , , 
      Thailand.
FAU - Tungtrongchitr, R
AU  - Tungtrongchitr R
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      , , Thailand.
FAU - Chaicumpa, W
AU  - Chaicumpa W
AD  - Department of Parasitology, Faculty of Medicine, Siriraj Hospital, , , Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170706
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Case-Control Studies
MH  - Dermatophagoides pteronyssinus/*immunology
MH  - Female
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Rhinitis, Allergic, Perennial/etiology/*genetics/immunology
MH  - Thailand
EDAT- 2017/07/12 06:00
MHDA- 2017/10/20 06:00
CRDT- 2017/07/11 06:00
PHST- 2017/07/11 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
AID - gmr-16-03-gmr.16039641 [pii]
AID - 10.4238/gmr16039641 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 Jul 6;16(3). doi: 10.4238/gmr16039641.