PMID- 28692816
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20180904
IS  - 1448-5990 (Electronic)
IS  - 1031-3613 (Linking)
VI  - 30
IP  - 2
DP  - 2018 Jan
TI  - Unique oestrogen receptor ligand-binding domain sequence of native parrots: a 
      possible link between phytoestrogens and breeding success.
PG  - 262-271
LID - 10.1071/RD17045 [doi]
AB  - The New Zealand (NZ) native parrots kakapo, kaka and kea are classified as 
      critically endangered, endangered and vulnerable respectively. Successful 
      reproduction of kakapo and kaka is linked to years of high levels of fruiting in 
      native flora (mast years). To assess a possible hormonal link between native 
      plants and reproductive success in these parrots in mast years, we examined the 
      ligand-binding domains (LBD) of the progesterone receptor (PR), androgen receptor 
      (AR), estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) in NZ native 
      (kakapo, kaka, kea and kakariki) and non-native (Australian cockatiel) parrots 
      and compared them with those in the chicken. The amino acid sequences for PR, AR, 
      ESR1 and ESR2 shared >90% homology among the NZ parrots, the cockatiel and, in 
      most cases, the chicken. The exception was for the ESR1 LBD, which contained an 
      extra eight amino acids at the C-terminal in all the parrots compared with the 
      chicken and with published sequences of non-parrot species. These results support 
      the notion that the ESR1 LBD of parrots responds differently to putative 
      oestrogenic compounds in native trees in NZ during times of intermittent masting. 
      In turn, this may provide important information for generating parrot-specific 
      bioassays and linkages to steroidogenic activity in native plants.
FAU - Davis, Catherine E J
AU  - Davis CEJ
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
FAU - Bibby, Adrian H
AU  - Bibby AH
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
FAU - Buckley, Kevin M
AU  - Buckley KM
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
FAU - McNatty, Kenneth P
AU  - McNatty KP
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
FAU - Pitman, Janet L
AU  - Pitman JL
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Reprod Fertil Dev
JT  - Reproduction, fertility, and development
JID - 8907465
RN  - 0 (Avian Proteins)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Ligands)
RN  - 0 (Phytoestrogens)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Avian Proteins/chemistry/genetics/*metabolism
MH  - Binding Sites
MH  - Chickens/metabolism
MH  - Cockatoos/metabolism
MH  - *Diet
MH  - *Endangered Species
MH  - Estrogen Receptor alpha/chemistry/genetics/*metabolism
MH  - Estrogen Receptor beta/metabolism
MH  - Ligands
MH  - Molecular Docking Simulation
MH  - Parrots/genetics/*metabolism
MH  - Phytoestrogens/*metabolism
MH  - Plants/*metabolism
MH  - Protein Domains
MH  - Receptors, Androgen/metabolism
MH  - Receptors, Progesterone/metabolism
MH  - *Reproduction
MH  - Species Specificity
MH  - Structure-Activity Relationship
EDAT- 2017/07/12 06:00
MHDA- 2018/09/05 06:00
CRDT- 2017/07/11 06:00
PHST- 2017/02/07 00:00 [received]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2017/07/11 06:00 [entrez]
AID - RD17045 [pii]
AID - 10.1071/RD17045 [doi]
PST - ppublish
SO  - Reprod Fertil Dev. 2018 Jan;30(2):262-271. doi: 10.1071/RD17045.