PMID- 28693195
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 14
IP  - 1
DP  - 2017 Jul
TI  - MicroRNA-125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell 
      growth and motility.
PG  - 480-486
LID - 10.3892/ol.2017.6155 [doi]
AB  - A majority of studies have indicated that microRNA-125b (miR-125b) is aberrantly 
      expressed in various types of cancer. However, there are no studies on the 
      expression and function of miR-125b in human laryngeal squamous cell carcinoma 
      (LSCC). In the present study, miR-125b expression in LSCC sample tissues, 
      corresponding adjacent non-neoplastic tissues, LSCC cell lines and a normal human 
      keratinocyte cell line was measured using the reverse transcription-quantitative 
      polymerase chain reaction. Following transfection with miR-125b mimics, the Cell 
      Counting Kit-8, cell migration, cell invasion, western blotting and 
      dual-luciferase reporter assays were performed on LSCC cell lines. According to 
      the results, miR-125b was observed to be significantly downregulated in LSCC, and 
      its expression was significantly associated with clinical stage and alcohol 
      history. miR-125b was also observed to decrease cell growth, migration and 
      invasion in LSCC cells by directly targeting signal transducer and activator of 
      transcription 3. The results of the present study suggested that miR-125b may be 
      a potential treatment target of LSCC in the future.
FAU - Feng, Juan
AU  - Feng J
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang Uyghur 830054, P.R. China.
FAU - Fan, Yuqin
AU  - Fan Y
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang Uyghur 830054, P.R. China.
FAU - Ayiheng, Qukuerhan
AU  - Ayiheng Q
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang Uyghur 830054, P.R. China.
FAU - Zhang, Hua
AU  - Zhang H
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang Uyghur 830054, P.R. China.
FAU - Yong, Jun
AU  - Yong J
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang Uyghur 830054, P.R. China.
FAU - Hu, Bin
AU  - Hu B
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang Uyghur 830054, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170511
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5494609
OTO - NOTNLM
OT  - laryngeal squamous cell carcinoma
OT  - microRNA-125b
OT  - signal transducer and activator of transcription 3
OT  - targeted therapy
EDAT- 2017/07/12 06:00
MHDA- 2017/07/12 06:01
PMCR- 2017/05/11
CRDT- 2017/07/12 06:00
PHST- 2015/07/28 00:00 [received]
PHST- 2017/03/03 00:00 [accepted]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/07/12 06:01 [medline]
PHST- 2017/05/11 00:00 [pmc-release]
AID - OL-0-0-6155 [pii]
AID - 10.3892/ol.2017.6155 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Jul;14(1):480-486. doi: 10.3892/ol.2017.6155. Epub 2017 May 11.