PMID- 28693206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221109
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 14
IP  - 1
DP  - 2017 Jul
TI  - Role of T helper 17 cytokines in the tumour immune inflammation response of 
      patients with laryngeal squamous cell carcinoma.
PG  - 561-568
LID - 10.3892/ol.2017.6253 [doi]
AB  - Altered cytokine production can lead to immune dysfunction in patients with 
      cancer. The present study investigated the expression of T helper (Th)17 
      cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their 
      clinical significance in providing new therapeutic insights. The prevalence of 
      Th17 cells and their receptors in patients with LSCC was studied using 
      immunohistochemical analysis via tissue microarray technology. Flow cytometry was 
      used to investigate the percentage of Th17 and Th1 cells in peripheral blood 
      mononuclear cells. Furthermore, the proliferation of Th17 cells and 
      Th17-associated cytokines, including interleukin (IL)17, IL23 and RAR-related 
      orphan receptor gammat, was analyzed by reverse transcription-quantitative polymerase 
      chain reaction. The results revealed that the prevalence of Th17 cells in 
      patients with LSCC was elevated in their primary tumors, as well as in peripheral 
      blood, compared with that in healthy controls. It was further demonstrated that 
      Th17 cells could be induced and expanded in the tumor microenvironment through 
      cytokines produced by the tumor cells. In conclusion, Th17 cells have a 
      substantial impact on the carcinogenesis of LSCCs, and could serve as a potential 
      therapeutic target to modulate the anti-tumor response in these carcinomas.
FAU - Tang, Wei-Jing
AU  - Tang WJ
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Lu, Li-Ming
AU  - Lu LM
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, P.R. China.
FAU - Tang, Di
AU  - Tang D
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Shi, Xiao-Lin
AU  - Shi XL
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170525
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5494688
OTO - NOTNLM
OT  - IL17
OT  - IL23
OT  - LSCC
OT  - RORgammat
OT  - Th17
OT  - tumor microenvironment
EDAT- 2017/07/12 06:00
MHDA- 2017/07/12 06:01
PMCR- 2017/05/25
CRDT- 2017/07/12 06:00
PHST- 2015/09/06 00:00 [received]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/07/12 06:01 [medline]
PHST- 2017/05/25 00:00 [pmc-release]
AID - OL-0-0-6253 [pii]
AID - 10.3892/ol.2017.6253 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Jul;14(1):561-568. doi: 10.3892/ol.2017.6253. Epub 2017 May 25.