PMID- 28693306
OWN - NLM
STAT- MEDLINE
DCOM- 20180801
LR  - 20181113
IS  - 1976-555X (Electronic)
IS  - 1229-845X (Print)
IS  - 1229-845X (Linking)
VI  - 19
IP  - 1
DP  - 2018 Jan 31
TI  - Tannic acid-mediated immune activation attenuates Brucella abortus infection in 
      mice.
PG  - 51-57
LID - 10.4142/jvs.2018.19.1.51 [doi]
AB  - Brucellosis is an emerging infectious disease affecting humans and animals. In 
      this study, we investigated the in vitro and in vivo effects of tannic acid (TA) 
      against Brucella abortus infection. After infection, F-actin polymerization and 
      mitogen-activated protein kinases (MAPKs) (ERK 1/2 and p38alpha) phosphorylation were 
      reduced in TA-treated cells compared with that in control cells. The mice were 
      infected via an intraperitoneal route and were orally given TA or 
      phosphate-buffered saline for 14 days. Spleen weights of the TA-treated and 
      control mice were not different; however, splenic proliferation of B. abortus was 
      significantly reduced in the TA-treated group. Immune response analysis showed 
      that, compared with the control group, non-infected TA-treated mice displayed 
      increased levels of interferon-gamma (IFN-gamma), monocyte chemoattractant protein-1 
      (MCP-1), and interleukin-10 at 3 days post-infection and a further increase in 
      IFN-gamma and MCP-1 at 14 days post-infection. In contrast, compared with the control 
      group, infected TA-treated mice displayed elevated levels of IFN-gamma at 3 days 
      post-infection, which continued to increase at 14 days post-infection, as was 
      also observed for tumor necrosis factor. Taken together, the results showing TA 
      activation of cytokine production and inhibition of bacterial proliferation in 
      the host highlight a potential use of TA treatment in the control of Brucella 
      infection.
FAU - Reyes, Alisha W B
AU  - Reyes AWB
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
AD  - Department of Veterinary Paraclinical Sciences, College of Veterinary Medicine, 
      University of the Philippines Los Banos, Laguna 4031, Philippines.
FAU - Hop, Huynh T
AU  - Hop HT
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
FAU - Arayan, Lauren T
AU  - Arayan LT
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
FAU - Huy, Tran X N
AU  - Huy TXN
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
FAU - Min, Wongi
AU  - Min W
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
FAU - Lee, Hu Jang
AU  - Lee HJ
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
FAU - Chang, Hong Hee
AU  - Chang HH
AD  - Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 
      52828, Korea.
FAU - Kim, Suk
AU  - Kim S
AD  - Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National 
      University, Jinju 52828, Korea.
AD  - Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 
      52828, Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Vet Sci
JT  - Journal of veterinary science
JID - 100964185
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Tannins)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Brucella abortus/*drug effects
MH  - Brucellosis/*immunology/microbiology
MH  - Female
MH  - *Immunity, Innate
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Specific Pathogen-Free Organisms
MH  - Spleen/microbiology
MH  - Tannins/*pharmacology
PMC - PMC5799400
OTO - NOTNLM
OT  - Brucella abortus
OT  - actins
OT  - cytokines
OT  - mitogen-activated protein kinase
OT  - tannins
COIS- Conflict of Interest: The authors declare no conflicts of interest.
EDAT- 2017/07/12 06:00
MHDA- 2018/08/02 06:00
PMCR- 2018/01/01
CRDT- 2017/07/12 06:00
PHST- 2017/01/09 00:00 [received]
PHST- 2017/03/17 00:00 [revised]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/08/02 06:00 [medline]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - jvs.2016.108 [pii]
AID - 10.4142/jvs.2018.19.1.51 [doi]
PST - ppublish
SO  - J Vet Sci. 2018 Jan 31;19(1):51-57. doi: 10.4142/jvs.2018.19.1.51.