PMID- 28693405
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180611
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Linking)
VI  - 14
IP  - 1
DP  - 2017 Dec
TI  - Genetics and immunodysfunction underlying Behcet's disease and immunomodulant 
      treatment approaches.
PG  - 137-151
LID - 10.1080/1547691X.2017.1346008 [doi]
AB  - Behcet's disease (BD) is a chronic autoimmune condition primarily prevalent in 
      populations along the Mediterranean Sea. The exact etiology of BD has not been 
      fully explained yet, but the disease occurrence is associated with a genetic 
      factor, human leukocyte antigen (HLA)-B51 antigen. Among the various 
      immunodysfunctions that are found in BD, patients are increased neutrophil 
      motility and superoxide production, as well as elevated production of tumor 
      necrosis factor (TNF)-alpha and decreased production of interleukin (IL)-10. Elevated 
      levels of inflammatory cytokines like IL-1 and IL-17 in BD have been found 
      associated with aberrant expression of microRNA. Gene polymorphisms in BD 
      patients have been observed in molecules involved in responses to pathogens that 
      can ultimately modulate the host antimicrobial response. Moreover, several single 
      nucleotide polymorphisms (SNPs) have been reported in genes encoding chemokines 
      and adhesion molecules; many of these changes manifest as increases in vascular 
      inflammation and vascular damage. Lastly, genetic and epigenetic changes have 
      been suggested as involved in the pathogenesis of BD. Modifications in DNA 
      methylation have been found in BD patient monocytes and lymphocytes, leading to 
      adverse function of these cells. This review presents a comprehensive compilation 
      of the literature with regard to the immunodysfunction underlying BD, as well as 
      of the genetics, newly described clinical specifications and novel treatment 
      strategies using immunomodulants based on the current understanding of BD.
FAU - Salmaninejad, Arash
AU  - Salmaninejad A
AUID- ORCID: 0000-0001-6141-3915
AD  - a Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , 
      Iran.
AD  - b Medical Genetics Research Center, Student Research Committee, Department of 
      Medical Genetics, Faculty of Medicine , Mashhad University of Medical Sciences , 
      Mashhad , Iran.
AD  - c Rheumatology Research Center , Tehran University of Medical Sciences , Tehran , 
      Iran.
FAU - Gowhari, Arezoo
AU  - Gowhari A
AD  - d Department of Immunology, Faculty of Medicine , Mashhad University of Medical 
      Sciences , Mashhad , Iran.
FAU - Hosseini, Seyedmojtaba
AU  - Hosseini S
AD  - b Medical Genetics Research Center, Student Research Committee, Department of 
      Medical Genetics, Faculty of Medicine , Mashhad University of Medical Sciences , 
      Mashhad , Iran.
FAU - Aslani, Saeed
AU  - Aslani S
AD  - c Rheumatology Research Center , Tehran University of Medical Sciences , Tehran , 
      Iran.
FAU - Yousefi, Meysam
AU  - Yousefi M
AD  - b Medical Genetics Research Center, Student Research Committee, Department of 
      Medical Genetics, Faculty of Medicine , Mashhad University of Medical Sciences , 
      Mashhad , Iran.
FAU - Bahrami, Tayyeb
AU  - Bahrami T
AD  - e Genetics Research Center , University of Social Welfare and Rehabilitation 
      Sciences , Tehran , Iran.
FAU - Ebrahimi, Masoume
AU  - Ebrahimi M
AD  - f Department of Biology, Faculty of Sciences , University of Guilan , Rasht , 
      Iran.
FAU - Nesaei, Abolfazl
AU  - Nesaei A
AD  - g Department of Basic Sciences , Gonabad University of Medical Sciences , Gonabad 
      , Iran.
FAU - Zal, Masoud
AU  - Zal M
AD  - h Department of Medical Genetics , Shahid Beheshti University of Medical Sciences 
      , Tehran , Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-17)
RN  - 0 (MicroRNAs)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11062-77-4 (Superoxides)
SB  - IM
MH  - Behcet Syndrome/*genetics/*immunology
MH  - Cell Movement
MH  - DNA Methylation
MH  - Epigenesis, Genetic
MH  - Genetic Predisposition to Disease
MH  - HLA-B51 Antigen/*genetics
MH  - Humans
MH  - Immunomodulation
MH  - Interleukin-1/metabolism
MH  - Interleukin-17/metabolism
MH  - MicroRNAs/*genetics
MH  - Neutrophils/*immunology
MH  - Polymorphism, Single Nucleotide
MH  - Superoxides/metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
OTO - NOTNLM
OT  - Behcet's disease
OT  - clinical
OT  - genetics
OT  - immunology
OT  - treatment
EDAT- 2017/07/12 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/07/12 06:00
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 10.1080/1547691X.2017.1346008 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2017 Dec;14(1):137-151. doi: 10.1080/1547691X.2017.1346008.