PMID- 28693820
OWN - NLM
STAT- MEDLINE
DCOM- 20180517
LR  - 20180517
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1671
DP  - 2017 Sep 15
TI  - Central glucagon like peptide-1 inhibits reflex swallowing elicited by the 
      superior laryngeal nerve via caudal brainstem in the rat.
PG  - 26-32
LID - S0006-8993(17)30294-9 [pii]
LID - 10.1016/j.brainres.2017.07.004 [doi]
AB  - The effects of glucagon like peptide-1 (GLP-1) on reflex swallowing were examined 
      using anaesthetized rats. GLP-1 was injected into the dorsal vagal complex (DVC) 
      using glass micropipettes. Swallowing was induced by repeated electrical 
      stimulation of the central cut end of the superior laryngeal nerve (SLN) and was 
      identified by the electromyogram lead penetrated in the mylohyoide muscle through 
      bipolar electrodes. Microinjection of GLP-1 into the medial DVC (M-DVC) increased 
      the frequency of swallowing during the electrical stimulation of the SLN and 
      extended the latency of the first swallowing. Microinjection of GLP-1 into the 
      lateral DVC (L-DVC) did not change the frequency of swallowing or the latency of 
      the first swallowing. Neither the injection of vehicle into the M-DVC nor L-DVC 
      affected swallowing frequency. Pre-injection of exendin (5-39), a GLP-1 receptor 
      antagonist, attenuated the degree of suppression of swallowing frequency induced 
      by the administration of GLP-1 in addition to shortening the latency of the first 
      swallowing. To identify the effective site of GLP-1, lesion experiments were 
      performed. Electrical lesion of the commissural part of the NTS (cNTS) and the 
      vacuum removal of the area postrema (AP) did not affect the inhibition of reflex 
      swallowing induced by the injection of GLP-1 into the M-DVC. Electrical lesion of 
      the medial nucleus of the NTS (mNTS) and its vicinity abolished the inhibitory 
      effects of swallowing induced by the injection of GLP-1. These results suggest 
      that GLP-1 inhibits reflex swallowing via the mNTS in the dorsal medulla.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Kobashi, Motoi
AU  - Kobashi M
AD  - Department of Oral Physiology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan. Electronic 
      address: mkobashi@md.okayama-u.ac.jp.
FAU - Mizutani, Satoshi
AU  - Mizutani S
AD  - Department of Oral Physiology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
FAU - Fujita, Masako
AU  - Fujita M
AD  - Department of Oral Physiology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
FAU - Mitoh, Yoshihiro
AU  - Mitoh Y
AD  - Department of Oral Physiology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
FAU - Shimatani, Yuichi
AU  - Shimatani Y
AD  - Department of Medical Engineering, Faculty of Engineering, Tokyo City University, 
      Tokyo 158-8557, Japan.
FAU - Matsuo, Ryuji
AU  - Matsuo R
AD  - Department of Oral Physiology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170708
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Brain Stem/*drug effects/*physiology
MH  - Deglutition/*drug effects/*physiology
MH  - Electric Stimulation
MH  - Electromyography
MH  - Glucagon-Like Peptide 1/*pharmacology/physiology
MH  - Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors/metabolism
MH  - Laryngeal Nerves/*drug effects/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex/drug effects/physiology
MH  - Vagus Nerve/drug effects/physiology
OTO - NOTNLM
OT  - AP
OT  - GLP-1
OT  - Incretin
OT  - NTS
OT  - Swallowing
EDAT- 2017/07/12 06:00
MHDA- 2018/05/18 06:00
CRDT- 2017/07/12 06:00
PHST- 2017/04/11 00:00 [received]
PHST- 2017/06/30 00:00 [revised]
PHST- 2017/07/04 00:00 [accepted]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/05/18 06:00 [medline]
PHST- 2017/07/12 06:00 [entrez]
AID - S0006-8993(17)30294-9 [pii]
AID - 10.1016/j.brainres.2017.07.004 [doi]
PST - ppublish
SO  - Brain Res. 2017 Sep 15;1671:26-32. doi: 10.1016/j.brainres.2017.07.004. Epub 2017 
      Jul 8.