PMID- 28694753
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1611-2156 (Print)
IS  - 1611-2156 (Electronic)
IS  - 1611-2156 (Linking)
VI  - 16
DP  - 2017
TI  - Correlation of the plasma sphingoid base profile with results from oral glucose 
      tolerance tests in gestational diabetes mellitus.
PG  - 497-509
LID - 10.17179/excli2017-171 [doi]
AB  - Oral glucose tolerance test (OGTT) is usually insufficient to accurately predict 
      the risk for type 2 diabetes mellitus (T2DM), it is therefore necessary to 
      identify an additional biomarker that would most likely improve the accuracy of 
      OGTT. The current OGTT was performed in 53 volunteers after ingestion of 75 g 
      glucose in 250 ml water to each volunteer. Similarly the sphingoid base profile 
      of these volunteers was explored using liquid-chromatography linked with mass 
      spectrometer (LC-MS) and correlated with the different time-points glucose values 
      of OGTT as well as with total area under the curve (tAUC), incremental area under 
      the curve (iAUC), and positive incremental area under the curve (pAUC). The 
      findings showed that 1-deoxysphinganine (1-deoxySA) was significantly positively 
      correlated with the 1-hour, 2-hour, and 3-hour plasma glucose level as well as 
      with total, incremental, and positive incremental AUC while 1-deoxysphingosine 
      (1-deoxySO) was correlated only with 1-hour, 2-hour glucose levels and tAUC of 
      OGTT. The C18SAdiene was negatively correlated with all-time points glucose 
      values and AUCs followed by negative correlation of C18SO, C16SO and C17SO with 
      2-hour glucose and tAUC of OGTT. The ratios of 1-deoxySA and 1-deoxySO with 
      respect to C18SAdiene have shown significant correlation with 2-hour and AUCs. 
      These ratios were higher in subjects with gestational diabetes in comparison with 
      normal subjects. These findings underlined that 1-deoxysphingolipids (1-deoxySLs) 
      and their ratios with C18SAdiene could be significantly correlated with the 
      glucose load of OGTT and might be used as predictive biomarkers along with OGTT 
      for the risk assessment of diabetes.
FAU - Khan, Abad
AU  - Khan A
AD  - Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, 
      8091 Zurich, Switzerland.
AD  - Department of Pharmacy, University of Swabi, Khyber Pakhtunkhwa, Pakistan.
FAU - Hornemann, Thorsten
AU  - Hornemann T
AD  - Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, 
      8091 Zurich, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - Germany
TA  - EXCLI J
JT  - EXCLI journal
JID - 101299402
PMC - PMC5491909
OTO - NOTNLM
OT  - area under the curve
OT  - basal glucose
OT  - correlation
OT  - gestational diabetes
OT  - oral glucose tolerance test
OT  - sphingoid-bases
EDAT- 2017/07/12 06:00
MHDA- 2017/07/12 06:01
PMCR- 2017/04/18
CRDT- 2017/07/12 06:00
PHST- 2017/01/24 00:00 [received]
PHST- 2017/03/28 00:00 [accepted]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/07/12 06:01 [medline]
PHST- 2017/04/18 00:00 [pmc-release]
AID - 2017-171 [pii]
AID - Doc497 [pii]
AID - 10.17179/excli2017-171 [doi]
PST - epublish
SO  - EXCLI J. 2017 Apr 18;16:497-509. doi: 10.17179/excli2017-171. eCollection 2017.