PMID- 28694754
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1611-2156 (Print)
IS  - 1611-2156 (Electronic)
IS  - 1611-2156 (Linking)
VI  - 16
DP  - 2017
TI  - Using curcumin to prevent structural and behavioral changes of medial prefrontal 
      cortex induced by sleep deprivation in rats.
PG  - 510-520
LID - 10.17179/excli2017-139 [doi]
AB  - Sleep Deprivation (SD) is known to result in a range of neurological consequences 
      in chronically-afflicted subjects. Curcumin, a natural substance, has 
      neuroprotective properties. This study aimed to evaluate the effects of curcumin 
      on the medial Prefrontal Cortex (mPFC) of SD rats. Male rats were arbitrarily 
      assigned to nine groups, including control, curcumin (100 mg/kg/day), olive oil, 
      SD, SD+curcumin, SD+olive oil, grid, grid+curcumin, and grid+olive oil groups. SD 
      was induced by a multiplatform box containing water. After a period of 21 days, 
      the learning and memory of the rats were tested in an eight-arm radial maze. 
      Afterwards, their brains were evaluated using stereological methods. Concomitant 
      treatment of curcumin during SD caused fewer errors during evaluation of the 
      working and reference memory errors in the acquisition and retention phases. The 
      overall volume of the mPFC, Infralimbic Cortex (ILC), Prelimbic Cortex (PLC), 
      Anterior Cingulate Cortex (ACC) and the total number of neurons and glial cells 
      reduced by 20 %-40 % on average in the SD animals in comparison to the control 
      group. This indicated atrophic changes and cell loss in these areas (p < 0.01). 
      The dendrites' length and the number of spines per dendrite also reduced by 35 
      %-55 % in the SD rats compared to the ones in the control group (p < 0.01). Yet, 
      treatment of the SD animals with curcumin prevented the atrophic changes of the 
      mPFC, cell loss, and dendritic changes (p < 0.05). SD induced structural changes 
      in the mPFC and memory impairment in the rats. However, curcumin could protect 
      their PFC.
FAU - Noorafshan, Ali
AU  - Noorafshan A
AD  - Histomorphometry and Stereology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
AD  - Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Karimi, Fatemeh
AU  - Karimi F
AD  - Histomorphometry and Stereology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
AD  - Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Karbalay-Doust, Saied
AU  - Karbalay-Doust S
AD  - Histomorphometry and Stereology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
AD  - Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Kamali, Ali Mohammad
AU  - Kamali AM
AD  - Histomorphometry and Stereology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
AD  - Department of Neuroscience, School of Advanced Medical Sciences and Technologies, 
      Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - Germany
TA  - EXCLI J
JT  - EXCLI journal
JID - 101299402
PMC - PMC5491911
OTO - NOTNLM
OT  - curcumin
OT  - mPFC
OT  - rat
OT  - sleep deprivation
OT  - stereology
EDAT- 2017/07/12 06:00
MHDA- 2017/07/12 06:01
PMCR- 2017/04/18
CRDT- 2017/07/12 06:00
PHST- 2017/01/11 00:00 [received]
PHST- 2017/03/20 00:00 [accepted]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/07/12 06:01 [medline]
PHST- 2017/04/18 00:00 [pmc-release]
AID - 2017-139 [pii]
AID - Doc510 [pii]
AID - 10.17179/excli2017-139 [doi]
PST - epublish
SO  - EXCLI J. 2017 Apr 18;16:510-520. doi: 10.17179/excli2017-139. eCollection 2017.