PMID- 28695160
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 2339-5478 (Print)
IS  - 2339-5478 (Linking)
VI  - 5
IP  - 1
DP  - 2017 Mar
TI  - Recent advances in nonbiofouling PDMS surface modification strategies applicable 
      to microfluidic technology.
PG  - 1-12
LID - 10.1142/S2339547817300013 [doi]
AB  - In the last decade microfabrication processes including rapid prototyping 
      techniques have advanced rapidly and achieved a fairly mature stage. These 
      advances have encouraged and enabled the use of microfluidic devices by a wider 
      range of users with applications in biological separations and cell and organoid 
      cultures. Accordingly, a significant current challenge in the field is 
      controlling biomolecular interactions at interfaces and the development of novel 
      biomaterials to satisfy the unique needs of the biomedical applications. 
      Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the 
      fabrication of microfluidic devices. The popularity of this material is the 
      result of its low cost, simple fabrication allowing rapid prototyping, high 
      optical transparency, and gas permeability. However, a major drawback of PDMS is 
      its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. 
      This results in significant nonspecific adsorption of proteins as well as small 
      hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in 
      biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances 
      in surface molecular treatments to prevent fouling of PDMS surfaces towards 
      improving its utility and expanding its use cases in biomedical applications.
FAU - Gokaltun, Aslihan
AU  - Gokaltun A
AD  - Center for Engineering in Medicine at Massachusetts General Hospital, Harvard 
      Medical School, and Shriners Hospital for Children, 51 Blossom St., Boston, MA 
      02114, USA.
AD  - Department of Chemical and Biological Engineering, Tufts University, 4 Colby 
      Street, Medford, MA 02474, USA.
AD  - Department of Chemical Engineering, Hacettepe University, 06532, Beytepe, Ankara, 
      Turkey.
FAU - Yarmush, Martin L
AU  - Yarmush ML
AD  - Center for Engineering in Medicine at Massachusetts General Hospital, Harvard 
      Medical School, and Shriners Hospital for Children, 51 Blossom St., Boston, MA 
      02114, USA.
AD  - Department of Biomedical Engineering, Rutgers University, 599 Taylor Rd., 
      Piscataway, NJ 08854, USA.
FAU - Asatekin, Ayse
AU  - Asatekin A
AD  - Department of Chemical and Biological Engineering, Tufts University, 4 Colby 
      Street, Medford, MA 02474, USA.
FAU - Usta, O Berk
AU  - Usta OB
AD  - Center for Engineering in Medicine at Massachusetts General Hospital, Harvard 
      Medical School, and Shriners Hospital for Children, 51 Blossom St., Boston, MA 
      02114, USA.
LA  - eng
GR  - P41 EB002503/EB/NIBIB NIH HHS/United States
GR  - R01 EB023812/EB/NIBIB NIH HHS/United States
GR  - R21 EB020192/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20170207
PL  - Singapore
TA  - Technology (Singap World Sci)
JT  - Technology
JID - 101622420
PMC - PMC5501164
MID - NIHMS867054
OTO - NOTNLM
OT  - Microchannels
OT  - Microfluidics
OT  - Nonspecific Protein Adsorption
OT  - PDMS
OT  - Small Molecule Absorption
OT  - Surface Modification
OT  - Tissue-on-Chips
EDAT- 2017/07/12 06:00
MHDA- 2017/07/12 06:01
PMCR- 2018/03/01
CRDT- 2017/07/12 06:00
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/07/12 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1142/S2339547817300013 [doi]
PST - ppublish
SO  - Technology (Singap World Sci). 2017 Mar;5(1):1-12. doi: 
      10.1142/S2339547817300013. Epub 2017 Feb 7.