PMID- 28695293
OWN - NLM
STAT- MEDLINE
DCOM- 20170929
LR  - 20181113
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 69
IP  - 8-9
DP  - 2017 Aug
TI  - HLA class II and rheumatoid arthritis: the bumpy road of revelation.
PG  - 597-603
LID - 10.1007/s00251-017-0987-5 [doi]
AB  - Rheumatoid arthritis (RA) is a chronic auto-immune disease primarily targeting 
      the joints. Approximately 1% of the population is affected by RA, and despite the 
      improvements in therapeutic interventions, elucidation of the disease 
      pathogenesis is still in its infancy. RA patients can be subdivided on basis of 
      the presence of autoantibodies, especially anti-citrullinated protein antibodies 
      (ACPA). ACPA(+) and ACPA(-) disease most likely differ in aetiology, as different 
      genetic and environmental risk factors are associated with these two disease 
      entities. For ACPA(+) RA disease, the genetic factors associating with disease 
      mainly comprised of human leukocyte antigen (HLA) class II molecules. The 
      predisposing HLA-DR alleles have been depicted as the 'HLA Shared Epitope (SE) 
      alleles', as these alleles encode a similar sequence, the shared epitope 
      sequence, within the beta chain of the HLA-DR molecule. In addition to the 
      involvement of the HLA-SE alleles in the development of ACPA(+) RA disease, other 
      HLA-DR molecules have been shown to confer protection against this disease 
      entity. The protective HLA molecules have, instead of the SE-motif, a different 
      but shared sequence at the same location in the beta chain of HLA-DR molecules, 
      consisting of the amino acid residues DERAA. The possible contributions of the 
      predisposing and protective HLA molecules in association with ACPA-positive RA 
      are discussed in this review.
FAU - Kampstra, Arieke S B
AU  - Kampstra ASB
AD  - Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 
      2300RC, Leiden, The Netherlands. a.s.b.kampstra@lumc.nl.
FAU - Toes, Rene E M
AU  - Toes REM
AD  - Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 
      2300RC, Leiden, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170711
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Epitopes)
RN  - 0 (HLA-DR Antigens)
RN  - 29VT07BGDA (Citrulline)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Arthritis, Rheumatoid/*immunology
MH  - Citrulline/immunology
MH  - Epitopes
MH  - HLA-DR Antigens/*genetics/physiology
MH  - Humans
MH  - Mice
PMC - PMC5537318
OTO - NOTNLM
OT  - ACPA+ disease
OT  - DERAA
OT  - HLA class II molecules
OT  - Rheumatoid arthritis
OT  - Shared epitope
OT  - T cells
EDAT- 2017/07/12 06:00
MHDA- 2017/09/30 06:00
PMCR- 2017/07/11
CRDT- 2017/07/12 06:00
PHST- 2017/04/14 00:00 [received]
PHST- 2017/04/18 00:00 [accepted]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/09/30 06:00 [medline]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/11 00:00 [pmc-release]
AID - 10.1007/s00251-017-0987-5 [pii]
AID - 987 [pii]
AID - 10.1007/s00251-017-0987-5 [doi]
PST - ppublish
SO  - Immunogenetics. 2017 Aug;69(8-9):597-603. doi: 10.1007/s00251-017-0987-5. Epub 
      2017 Jul 11.