PMID- 28695657
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20221207
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Print)
IS  - 2059-2302 (Linking)
VI  - 90
IP  - 4
DP  - 2017 Oct
TI  - HLA haplotypes in primary sclerosing cholangitis patients of admixed and 
      non-European ancestry.
PG  - 228-233
LID - 10.1111/tan.13076 [doi]
AB  - Primary sclerosing cholangitis (PSC) is strongly associated with several human 
      leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and 
      multiple polymorphic candidate genes in the HLA complex, identifying the alleles 
      responsible for these associations has proven difficult. We aimed to evaluate 
      whether studying populations of admixed or non-European descent could help in 
      defining the causative HLA alleles. When assessing haplotypes carrying 
      HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to 
      chronic cholangitis), we observed that every haplotype in the Scandinavian PSC 
      population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 
      haplotypes in an admixed/non-European PSC population carried this allele, 
      suggesting that further assessments of the PSC-associated haplotype 
      HLA-DRB1*13:01-DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could 
      aid in identifying the causative allele.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Henriksen, E K K
AU  - Henriksen EKK
AUID- ORCID: 0000-0002-8105-6246
AD  - Norwegian PSC Research Center, Department of Transplantation Medicine, Division 
      of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
AD  - Research Institute of Internal Medicine, Division of Surgery, Inflammatory 
      Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Viken, M K
AU  - Viken MK
AUID- ORCID: 0000-0002-3917-9269
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
FAU - Wittig, M
AU  - Wittig M
AD  - Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
FAU - Holm, K
AU  - Holm K
AD  - Norwegian PSC Research Center, Department of Transplantation Medicine, Division 
      of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
AD  - Research Institute of Internal Medicine, Division of Surgery, Inflammatory 
      Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Folseraas, T
AU  - Folseraas T
AD  - Norwegian PSC Research Center, Department of Transplantation Medicine, Division 
      of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
AD  - Research Institute of Internal Medicine, Division of Surgery, Inflammatory 
      Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Section of Gastroenterology, Department of Transplantation Medicine, Division of 
      Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
FAU - Mucha, S
AU  - Mucha S
AD  - Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
FAU - Melum, E
AU  - Melum E
AD  - Norwegian PSC Research Center, Department of Transplantation Medicine, Division 
      of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
AD  - Research Institute of Internal Medicine, Division of Surgery, Inflammatory 
      Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Section of Gastroenterology, Department of Transplantation Medicine, Division of 
      Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
FAU - Hov, J R
AU  - Hov JR
AD  - Norwegian PSC Research Center, Department of Transplantation Medicine, Division 
      of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
AD  - Research Institute of Internal Medicine, Division of Surgery, Inflammatory 
      Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Section of Gastroenterology, Department of Transplantation Medicine, Division of 
      Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
FAU - Lazaridis, K N
AU  - Lazaridis KN
AD  - Center for Basic Research in Digestive Diseases, Division of Gastroenterology and 
      Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
FAU - Juran, B D
AU  - Juran BD
AD  - Center for Basic Research in Digestive Diseases, Division of Gastroenterology and 
      Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
FAU - Chazouilleres, O
AU  - Chazouilleres O
AD  - Hopital Saint-Antoine, Service d'Hepatologie, INSERM, UMR_S 938, CDR 
      Saint-Antoine, and Sorbonne Universites, UPMC Univ Paris 06, Paris, France.
FAU - Farkkila, M
AU  - Farkkila M
AD  - Helsinki University and Clinic of Gastroenterology, Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Gotthardt, D N
AU  - Gotthardt DN
AD  - Department of Gastroenterology, Infectious Diseases and Intoxications, University 
      Hospital of Heidelberg, Heidelberg, Germany.
FAU - Invernizzi, P
AU  - Invernizzi P
AD  - Program for Autoimmune Liver Diseases, International Center for Digestive Health, 
      Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
FAU - Carbone, M
AU  - Carbone M
AD  - Program for Autoimmune Liver Diseases, International Center for Digestive Health, 
      Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
FAU - Hirschfield, G M
AU  - Hirschfield GM
AD  - Centre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, 
      Institute of Biomedical Research, Institute of Immunology and Immunotherapy, 
      University of Birmingham, Birmingham, UK.
FAU - Rushbrook, S M
AU  - Rushbrook SM
AD  - The Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Norfolk, UK.
FAU - Goode, E
AU  - Goode E
AD  - Wellcome Trust Sanger Institute, Hinxton and Institute of Metabolic Science, 
      University of Cambridge, Cambridge, UK.
CN  - UK-PSC Consortium
FAU - Ponsioen, C Y
AU  - Ponsioen CY
AD  - Department of Gastroenterology and Hepatology, Academic Medical Center, 
      Amsterdam, the Netherlands.
FAU - Weersma, R K
AU  - Weersma RK
AD  - Department of Gastroenterology and Hepatology, University of Groningen, 
      University Medical Center Groningen, Groningen, the Netherlands.
FAU - Eksteen, B
AU  - Eksteen B
AD  - Snyder Institute for Chronic Diseases, Division of Gastroenterology, University 
      of Calgary, Calgary, Canada.
FAU - Yimam, K K
AU  - Yimam KK
AD  - Division of Hepatology and Liver Transplantation, California Pacific Medical 
      Center, San Francisco, California.
FAU - Gordon, S C
AU  - Gordon SC
AD  - Division of Gastroenterology and Hepatology, Henry Ford Health System, Detroit, 
      Michigan.
FAU - Goldberg, D
AU  - Goldberg D
AD  - Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Yu, L
AU  - Yu L
AD  - Department of Medicine, University of Washington, Seattle, Washington.
FAU - Bowlus, C L
AU  - Bowlus CL
AD  - Division of Gastroenterology and Hepatology, University of California Davis 
      School of Medicine, Sacramento, California.
FAU - Franke, A
AU  - Franke A
AD  - Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
FAU - Lie, B A
AU  - Lie BA
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
AD  - Department of Medical Genetics, University of Oslo and Oslo University Hospital 
      Ulleval, Oslo, Norway.
FAU - Karlsen, T H
AU  - Karlsen TH
AD  - Norwegian PSC Research Center, Department of Transplantation Medicine, Division 
      of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
AD  - Research Institute of Internal Medicine, Division of Surgery, Inflammatory 
      Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
AD  - K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Section of Gastroenterology, Department of Transplantation Medicine, Division of 
      Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
LA  - eng
GR  - R01 DK084960/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20170711
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Cholangitis, Sclerosing/ethnology/*genetics/immunology
MH  - Ethnicity
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/classification/*genetics/immunology
MH  - HLA-DRB1 Chains/classification/*genetics/immunology
MH  - *Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Scandinavian and Nordic Countries
MH  - White People
PMC - PMC7359736
MID - NIHMS891905
OTO - NOTNLM
OT  - PSC
OT  - causative
OT  - human leukocyte antigen
OT  - multi-ethnic
OT  - trans-ancestry
COIS- CONFLICT OF INTEREST The authors confirm that there are no conflicts of interest.
EDAT- 2017/07/12 06:00
MHDA- 2018/05/16 06:00
PMCR- 2020/07/14
CRDT- 2017/07/12 06:00
PHST- 2017/03/11 00:00 [received]
PHST- 2017/05/26 00:00 [revised]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2020/07/14 00:00 [pmc-release]
AID - 10.1111/tan.13076 [doi]
PST - ppublish
SO  - HLA. 2017 Oct;90(4):228-233. doi: 10.1111/tan.13076. Epub 2017 Jul 11.