PMID- 28696287
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20190207
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 114
IP  - 30
DP  - 2017 Jul 25
TI  - Genomic architecture of biomass heterosis in Arabidopsis.
PG  - 8101-8106
LID - 10.1073/pnas.1705423114 [doi]
AB  - Heterosis is most frequently manifested by the substantially increased vigorous 
      growth of hybrids compared with their parents. Investigating genomic variations 
      in natural populations is essential to understand the initial molecular 
      mechanisms underlying heterosis in plants. Here, we characterized the genomic 
      architecture associated with biomass heterosis in 200 Arabidopsis hybrids. The 
      genome-wide heterozygosity of hybrids makes a limited contribution to biomass 
      heterosis, and no locus shows an obvious overdominance effect in hybrids. 
      However, the accumulation of significant genetic loci identified in genome-wide 
      association studies (GWAS) in hybrids strongly correlates with better-parent 
      heterosis (BPH). Candidate genes for biomass BPH fall into diverse biological 
      functions, including cellular, metabolic, and developmental processes and 
      stimulus-responsive pathways. Important heterosis candidates include WUSCHEL, 
      ARGOS, and some genes that encode key factors involved in cell cycle regulation. 
      Interestingly, transcriptomic analyses in representative Arabidopsis hybrid 
      combinations reveal that heterosis candidate genes are functionally enriched in 
      stimulus-responsive pathways, including responses to biotic and abiotic stimuli 
      and immune responses. In addition, stimulus-responsive genes are repressed to 
      low-parent levels in hybrids with high BPH, whereas middle-parent expression 
      patterns are exhibited in hybrids with no BPH. Our study reveals a genomic 
      architecture for understanding the molecular mechanisms of biomass heterosis in 
      Arabidopsis, in which the accumulation of the superior alleles of genes involved 
      in metabolic and cellular processes improve the development and growth of 
      hybrids, whereas the overall repressed expression of stimulus-responsive genes 
      prioritizes growth over responding to environmental stimuli in hybrids under 
      normal conditions.
FAU - Yang, Mei
AU  - Yang M
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Wang, Xuncheng
AU  - Wang X
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Ren, Diqiu
AU  - Ren D
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Huang, Hao
AU  - Huang H
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Xu, Miqi
AU  - Xu M
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - He, Guangming
AU  - He G
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China deng@pku.edu.cn 
      heguangming@pku.edu.cn.
FAU - Deng, Xing Wang
AU  - Deng XW
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agricultural Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China deng@pku.edu.cn 
      heguangming@pku.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170710
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Arabidopsis/*genetics/growth & development
MH  - Biomass
MH  - Genome, Plant
MH  - Genome-Wide Association Study
MH  - *Hybrid Vigor
PMC - PMC5544317
OTO - NOTNLM
OT  - Arabidopsis
OT  - GWAS
OT  - biomass heterosis
OT  - natural variation
COIS- The authors declare no conflict of interest.
EDAT- 2017/07/12 06:00
MHDA- 2018/06/07 06:00
PMCR- 2018/01/25
CRDT- 2017/07/12 06:00
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2018/01/25 00:00 [pmc-release]
AID - 1705423114 [pii]
AID - 201705423 [pii]
AID - 10.1073/pnas.1705423114 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8101-8106. doi: 
      10.1073/pnas.1705423114. Epub 2017 Jul 10.