PMID- 28696399
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 7
DP  - 2017 Jul 11
TI  - Dendritic Cells and Their Role in Allergy: Uptake, Proteolytic Processing and 
      Presentation of Allergens.
LID - 10.3390/ijms18071491 [doi]
LID - 1491
AB  - Dendritic cells (DCs) are the most important antigen presenting cells to activate 
      naive T cells, which results in the case of Type 1 allergies in a Type 2 helper T 
      cell (Th2)-driven specific immune response towards allergens. So far, a number of 
      different subsets of specialized DCs in different organs have been identified. In 
      the recent past methods to study the interaction of DCs with allergenic proteins, 
      their different uptake and processing mechanisms followed by the presentation to 
      T cells were developed. The following review aims to summarize the most important 
      characteristics of DC subsets in the context of allergic diseases, and highlights 
      the recent findings. These detailed studies can contribute to a better 
      understanding of the pathomechanisms of allergic diseases and contribute to the 
      identification of key factors to be addressed for therapeutic interventions.
FAU - Humeniuk, Piotr
AU  - Humeniuk P
AD  - Department of Pathophysiology and Allergy Research, Center for Pathophysiology, 
      Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria. 
      piotr.humeniuk@meduniwien.ac.at.
FAU - Dubiela, Pawel
AU  - Dubiela P
AD  - Department of Pathophysiology and Allergy Research, Center for Pathophysiology, 
      Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria. 
      pawel.dubiela@meduniwien.ac.at.
FAU - Hoffmann-Sommergruber, Karin
AU  - Hoffmann-Sommergruber K
AD  - Department of Pathophysiology and Allergy Research, Center for Pathophysiology, 
      Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria. 
      karin.hoffmann@meduniwien.ac.at.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170711
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*metabolism
MH  - Animals
MH  - Antigen Presentation/physiology
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - Hypersensitivity/*metabolism
MH  - T-Lymphocytes/metabolism
PMC - PMC5535981
OTO - NOTNLM
OT  - allergens
OT  - dendritic cells
OT  - presentation
OT  - processing
OT  - uptake
COIS- The authors declare not conflicts of interest.
EDAT- 2017/07/12 06:00
MHDA- 2018/04/18 06:00
PMCR- 2017/07/01
CRDT- 2017/07/12 06:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/07/04 00:00 [revised]
PHST- 2017/07/05 00:00 [accepted]
PHST- 2017/07/12 06:00 [entrez]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - ijms18071491 [pii]
AID - ijms-18-01491 [pii]
AID - 10.3390/ijms18071491 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Jul 11;18(7):1491. doi: 10.3390/ijms18071491.