PMID- 2869739
OWN - NLM
STAT- MEDLINE
DCOM- 19860328
LR  - 20131121
IS  - 0003-9926 (Print)
IS  - 0003-9926 (Linking)
VI  - 146
IP  - 3
DP  - 1986 Mar
TI  - Serum gastrin level is increased by chronic hypercalcemia of parathyroid or 
      nonparathyroid origin.
PG  - 478-82
AB  - In patients with hypercalcemia with abdominal symptoms, gastrin concentration is 
      often measured to exclude the Zollinger-Ellison syndrome. We found that 
      interpretation of such measurements is clouded by a contradictory literature. We 
      therefore measured serum gastrin concentrations in 78 patients with primary 
      hyperparathyroidism, 36 with nonparathyroid hypercalcemia, 13 with hypocalcemia, 
      and 33 normocalcemic controls. Gastrin values above normal occurred in 22% of 
      those with primary hyperparathyroidism and 28% of those with nonparathyroid 
      hypercalcemia. Values above 250 pg/mL occurred only in those with hypochlorhydria 
      or multiple endocrine neoplasia, type 1 (MEN 1). After parathyroidectomy, gastrin 
      levels fell significantly, but elevated values tended to recur in those with MEN 
      1 if hypercalcemia recurred. Thus, chronic hypercalcemia of either parathyroid or 
      nonparathyroid origin may elevate serum gastrin concentrations, but marked 
      elevations suggest either achlorhydria or MEN 1.
FAU - Zaniewski, M
AU  - Zaniewski M
FAU - Jordan, P H Jr
AU  - Jordan PH Jr
FAU - Yip, B
AU  - Yip B
FAU - Thornby, J I
AU  - Thornby JI
FAU - Mallette, L E
AU  - Mallette LE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Gastrins)
RN  - 0 (Parathyroid Hormone)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/metabolism
MH  - Chronic Disease
MH  - Creatinine/metabolism
MH  - Diagnosis, Differential
MH  - Gastrins/*blood
MH  - Humans
MH  - Hypercalcemia/*metabolism
MH  - Hyperparathyroidism/blood/*metabolism
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/blood/*metabolism
MH  - Parathyroid Hormone/blood
MH  - Radioimmunoassay
EDAT- 1986/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1986/03/01 00:00
PHST- 1986/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1986/03/01 00:00 [entrez]
PST - ppublish
SO  - Arch Intern Med. 1986 Mar;146(3):478-82.