PMID- 28697579
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20180806
IS  - 1095-9114 (Electronic)
IS  - 0895-3996 (Linking)
VI  - 25
IP  - 6
DP  - 2017
TI  - Can low-dose CT perfusion imaging accurately assess response of advanced gastric 
      cancer with neoadjuvant chemotherapy?
PG  - 981-991
LID - 10.3233/XST-17271 [doi]
AB  - PURPOSE: To explore the value of low-dose CT perfusion imaging (LDCTPI) 
      technology and its perfusion parameters in assessing response of neoadjuvant 
      chemotherapy (NAC) in patients with advanced gastric cancer (AGC). METHODS: 
      Thirty patients with AGC were studied prospectively by LDCTPI to measure two 
      parameters including blood flow (BF) and blood volume (BV) of tumor area before 
      and after chemotherapy, respectively. All of the patients received two courses of 
      NAC and surgical resection of gastric tumor within one week after chemotherapy, 
      and then obtained the result of postoperative pathology response for 
      chemotherapy. The comparisons of BF and BV values of AGC before and after 
      chemotherapy were analyzed by paired-samples t-test, respectively; and the 
      correlations between BF as well as BV decrease rates after NAC and the pathology 
      response grade were analyzed by Spearman statistical test. Thirty patients were 
      divided into effective and ineffective groups according to different pathology 
      response grade. Comparisons of BF as well as BV decrease rates between effective 
      and ineffective groups were analyzed by independent-samples t-test, respectively. 
      Receiver operating characteristic (ROC) curves were used to determine the cutoff 
      values of BF and BV decrease rates as evaluation indicators of AGC after NAC and 
      calculate area under the curve (AUC). RESULTS: There were significant differences 
      in BF and BV values of AGC between before and after NAC (p < 0.001), 
      respectively, and there were obvious correlations between BF as well as BV 
      decrease rates and pathology response grade (r = 0.660, p < 0.001; r = 0.706, 
      p < 0.001), respectively. There were also significant differences in BF and BV 
      decrease rates of AGC between effective and ineffective groups (P = 0.001), 
      respectively. If BF decrease rate of 12.1% (AUC was 0.816, P = 0.005) was used as 
      the cutoff value for chemotherapy effectiveness of AGC, the sensitivity of 82% 
      and specificity of 84% were achieved, and if BV decrease rate of 32.8% (AUC was 
      0.844, P = 0.002) was used as the cutoff value for chemotherapy effectiveness of 
      AGC, the sensitivity of 82% and specificity of 89% were achieved. CONCLUSIONS: BF 
      and BV decrease rates have potential to be used as effective indicators to assess 
      chemotherapy efficacy of AGC from the hemodynamics.
FAU - Sun, Zong-Qiong
AU  - Sun ZQ
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Forth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Yan, Gen
AU  - Yan G
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Forth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Ge, Yu-Xi
AU  - Ge YX
AD  - Department of Radiology, Affiliated Hospital of Jiangnan University, The Forth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Intervention, Affiliated Hospital of Jiangnan University, The Forth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Jin, Lin-Fang
AU  - Jin LF
AD  - Department of Pathology, Affiliated Hospital of Jiangnan University, The Forth 
      People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Xie, Zhi-Hui
AU  - Xie ZH
AD  - Department of Surgical Gastroenterology, Affiliated Hospital of Jiangnan 
      University, The Forth People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
FAU - Zhao, Peng
AU  - Zhao P
AD  - Departments of Neuroscience, Anatomy, Histology, and Embryology, Wuxi School of 
      Medicine, Jiangnan University, Wuxi, Jiangsu, China.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Xray Sci Technol
JT  - Journal of X-ray science and technology
JID - 9000080
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoadjuvant Therapy/*methods
MH  - Prospective Studies
MH  - *Radiation Dosage
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stomach/diagnostic imaging
MH  - Stomach Neoplasms/*diagnostic imaging/*drug therapy
MH  - Tomography, X-Ray Computed/*methods
OTO - NOTNLM
OT  - CT perfusion imaging
OT  - advanced gastric cancer
OT  - low-dose
OT  - neoadjuvant chemotherapy
OT  - pathological response
EDAT- 2017/07/13 06:00
MHDA- 2018/08/07 06:00
CRDT- 2017/07/13 06:00
PHST- 2017/07/13 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
PHST- 2017/07/13 06:00 [entrez]
AID - XST17271 [pii]
AID - 10.3233/XST-17271 [doi]
PST - ppublish
SO  - J Xray Sci Technol. 2017;25(6):981-991. doi: 10.3233/XST-17271.