PMID- 2869856
OWN - NLM
STAT- MEDLINE
DCOM- 19860507
LR  - 20190919
IS  - 0141-9854 (Print)
IS  - 0141-9854 (Linking)
VI  - 7
IP  - 4
DP  - 1985
TI  - Dipeptidylaminopeptidase IV (DAP IV) in B- and T-cell leukaemias.
PG  - 359-68
AB  - A cytochemical study in samples from 100 lymphoid leukaemias, 84 of B-cell type 
      and 16 of T-cell type, was carried out with three acid hydrolases: DAP IV, acid 
      phosphatase (AP) and alpha-naphthyl acetate esterase (ANAE). DAP IV was studied 
      in leukaemic T-cells both by cytochemistry and by a monoclonal antibody with the 
      immunoperoxidase technique. Both methods showed similar results. AP and ANAE gave 
      weak reactions in immature B-cell leukaemias (common-ALL and B-CLL) and were 
      strongly expressed in plasma cell disorders. DAP IV showed no activity in any of 
      the types of B-cell leukaemia studied and was strongly positive in some T-cell 
      leukaemias but with a more restricted distribution than ANAE and AP. 
      T-lymphoblasts (T-ALL) and mature (T8+) leukaemias were DAP IV negative. Within 
      the T4+ malignancies DAP IV was positive in four T-prolymphocytic leukaemias, one 
      of two T-CLL and one of three Sezary syndrome cases. Although DAP IV is strictly 
      T-cell specific it does not appear to aid the differentiation between B- and 
      T-cell disorders or the identification of T-cell subsets as determined by 
      monoclonal antibodies. It remains to be established whether this enzyme will 
      define a functionally distinct T-cell subset.
FAU - Andrews, C
AU  - Andrews C
FAU - Crockard, A D
AU  - Crockard AD
FAU - San Miguel, J F
AU  - San Miguel JF
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Clin Lab Haematol
JT  - Clinical and laboratory haematology
JID - 7907061
RN  - EC 3.1.- (Naphthol AS D Esterase)
RN  - EC 3.1.3.2 (Acid Phosphatase)
RN  - EC 3.4.14.- (Dipeptidyl-Peptidases and Tripeptidyl-Peptidases)
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
SB  - IM
MH  - Acid Phosphatase/metabolism
MH  - B-Lymphocytes/*enzymology
MH  - Dipeptidyl Peptidase 4
MH  - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*metabolism
MH  - Histocytochemistry
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Leukemia/*enzymology
MH  - Leukemia, Lymphoid/enzymology
MH  - Naphthol AS D Esterase/metabolism
MH  - Sezary Syndrome/enzymology
MH  - T-Lymphocytes/classification/*enzymology
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1111/j.1365-2257.1985.tb00050.x [doi]
PST - ppublish
SO  - Clin Lab Haematol. 1985;7(4):359-68. doi: 10.1111/j.1365-2257.1985.tb00050.x.