PMID- 28698626
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jul 11
TI  - A genome-wide association study suggests the HLA Class II region as the major 
      susceptibility locus for IgA vasculitis.
PG  - 5088
LID - 10.1038/s41598-017-03915-2 [doi]
LID - 5088
AB  - The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be 
      elucidated. To increase the current knowledge on the genetic component of this 
      vasculitis we performed the first genome-wide association study (GWAS) on this 
      condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were 
      genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed 
      using the 1000 Genomes Project Phase III dataset as reference panel. After 
      quality control filters and GWAS imputation, 285 patients and 1,006 controls 
      remained in the datasets and were included in further analysis. Additionally, the 
      human leukocyte antigen (HLA) region was comprehensively studied by imputing 
      classical alleles and polymorphic amino acid positions. A linkage disequilibrium 
      block of polymorphisms located in the HLA class II region surpassed the 
      genome-wide level of significance (OR = 0.56, 95% CI = 0.46-0.68). Although no 
      polymorphic amino acid positions were associated at the genome-wide level of 
      significance, P-values of potential relevance were observed for the positions 13 
      and 11 of HLA-DRB1 (P = 6.67E-05, P = 1.88E-05, respectively). Outside the HLA, 
      potential associations were detected, but none of them were close to the 
      statistical significance. In conclusion, our study suggests that IgA vasculitis 
      is an archetypal HLA class II disease.
FAU - Lopez-Mejias, Raquel
AU  - Lopez-Mejias R
AUID- ORCID: 0000-0003-0548-2689
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain. rlopezmejias78@gmail.com.
FAU - Carmona, F David
AU  - Carmona FD
AD  - Instituto de Parasitologia y Biomedicina 'Lopez-Neyra', CSIC, PTS Granada, 
      Granada, Spain.
AD  - Departamento de Genetica e Instituto de Biotecnologia, Universidad de Granada, 
      Granada, Spain.
FAU - Castaneda, Santos
AU  - Castaneda S
AD  - Rheumatology Department, Hospital Universitario La Princesa, IIS-IPrincesa, 
      Madrid, Spain.
FAU - Genre, Fernanda
AU  - Genre F
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
FAU - Remuzgo-Martinez, Sara
AU  - Remuzgo-Martinez S
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
FAU - Sevilla-Perez, Belen
AU  - Sevilla-Perez B
AD  - Medicine Department, Hospital Universitario San Cecilio, Granada, Spain.
FAU - Ortego-Centeno, Norberto
AU  - Ortego-Centeno N
AD  - Medicine Department, Hospital Universitario San Cecilio, Granada, Spain.
FAU - Llorca, Javier
AU  - Llorca J
AD  - Epidemiology and Computational Biology Department, School of Medicine, University 
      of Cantabria, and CIBER Epidemiologia y Salud Publica (CIBERESP), IDIVAL, 
      Santander, Spain.
FAU - Ubilla, Begona
AU  - Ubilla B
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
FAU - Mijares, Veronica
AU  - Mijares V
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
FAU - Pina, Trinitario
AU  - Pina T
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
FAU - Miranda-Filloy, Jose A
AU  - Miranda-Filloy JA
AD  - Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain.
FAU - Navas Parejo, Antonio
AU  - Navas Parejo A
AD  - Nephrology Department, Hospital Universitario San Cecilio, Granada, Spain.
FAU - de Argila, Diego
AU  - de Argila D
AD  - Dermatology Department, Hospital Universitario La Princesa, IIS-IPrincesa, 
      Madrid, Spain.
FAU - Aragues, Maximiliano
AU  - Aragues M
AD  - Dermatology Department, Hospital Universitario La Princesa, IIS-IPrincesa, 
      Madrid, Spain.
FAU - Rubio, Esteban
AU  - Rubio E
AD  - Rheumatology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
FAU - Luque, Manuel Leon
AU  - Luque ML
AD  - Rheumatology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
FAU - Blanco-Madrigal, Juan Maria
AU  - Blanco-Madrigal JM
AD  - Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain.
FAU - Galindez-Aguirregoikoa, Eva
AU  - Galindez-Aguirregoikoa E
AD  - Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain.
FAU - Jayne, David
AU  - Jayne D
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Blanco, Ricardo
AU  - Blanco R
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
FAU - Martin, Javier
AU  - Martin J
AD  - Instituto de Parasitologia y Biomedicina 'Lopez-Neyra', CSIC, PTS Granada, 
      Granada, Spain.
FAU - Gonzalez-Gay, Miguel A
AU  - Gonzalez-Gay MA
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de 
      Valdecilla, IDIVAL, Santander, Spain.
AD  - School of Medicine, University of Cantabria, Santander, Spain.
AD  - Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, 
      Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South 
      Africa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170711
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - *Genetic Loci
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Immunoglobulin A/*immunology
MH  - Logistic Models
MH  - Vasculitis/*genetics/*immunology
PMC - PMC5506002
COIS- The authors declare that they have no competing interests.
EDAT- 2017/07/13 06:00
MHDA- 2019/01/29 06:00
PMCR- 2017/07/11
CRDT- 2017/07/13 06:00
PHST- 2017/01/26 00:00 [received]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/07/13 06:00 [entrez]
PHST- 2017/07/13 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2017/07/11 00:00 [pmc-release]
AID - 10.1038/s41598-017-03915-2 [pii]
AID - 3915 [pii]
AID - 10.1038/s41598-017-03915-2 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jul 11;7(1):5088. doi: 10.1038/s41598-017-03915-2.