PMID- 28698767
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20181113
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2017
DP  - 2017
TI  - NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic 
      Testicular Damage.
PG  - 3172692
LID - 10.1155/2017/3172692 [doi]
LID - 3172692
AB  - Activation of nuclear factor erythroid 2-related factor 2 (NRF2) has been found 
      to ameliorate diabetic testicular damage (DTD) in rodents. However, it was 
      unclear whether NRF2 is required for these approaches in DTD. Epigallocatechin 
      gallate (EGCG) is a potent activator of NRF2 and has shown beneficial effects on 
      multiple diabetic complications. However, the effect of EGCG has not been studied 
      in DTD. The present study aims to explore the role of NRF2 in both self and EGCG 
      protection against DTD. Therefore, streptozotocin-induced diabetic C57BL/6 wild 
      type (WT) and Nrf2 knockout (KO) mice were treated in the presence or absence of 
      EGCG, for 24 weeks. The Nrf2 KO mice exhibited more significant diabetes-induced 
      loss in testicular weight and spermatozoa count, and increase in testicular 
      apoptotic cell death, as compared with the WT mice. EGCG activated NRF2 
      expression and function, preserved testicular weight and spermatozoa count, and 
      attenuated testicular apoptotic cell death, endoplasmic reticulum stress, 
      inflammation, and oxidative damage in the WT diabetic mice, but not the Nrf2 KO 
      diabetic mice. The present study demonstrated for the first time that NRF2 plays 
      a critical role in both self and EGCG protection against DTD.
FAU - Pan, Chenyu
AU  - Pan C
AD  - Department of Anesthesiology, The Second Hospital of Jilin University, 218 
      Ziqiang St., Changchun, Jilin 130041, China.
FAU - Zhou, Shengzhu
AU  - Zhou S
AD  - Department of Anesthesiology, The Second Hospital of Jilin University, 218 
      Ziqiang St., Changchun, Jilin 130041, China.
FAU - Wu, Junduo
AU  - Wu J
AD  - Department of Cardiology, The Second Hospital of Jilin University, 218 Ziqiang 
      St., Changchun, Jilin 130041, China.
FAU - Liu, Lingyun
AU  - Liu L
AD  - Department of Andrology, The First Hospital of Jilin University, 71 Xinmin St., 
      Changchun, Jilin 130021, China.
FAU - Song, Yanyan
AU  - Song Y
AD  - Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang 
      St., Changchun, Jilin 130041, China.
FAU - Li, Tie
AU  - Li T
AD  - Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, 
      1035 Boshuo Rd., Changchun, Jilin 130117, China.
AD  - The '973' National Basic Research Program of China, Changchun University of 
      Chinese Medicine, 1035 Boshuo Rd., Changchun, Jilin 130117, China.
FAU - Ha, Lijuan
AU  - Ha L
AD  - Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, 
      1035 Boshuo Rd., Changchun, Jilin 130117, China.
AD  - The '973' National Basic Research Program of China, Changchun University of 
      Chinese Medicine, 1035 Boshuo Rd., Changchun, Jilin 130117, China.
FAU - Liu, Xiaona
AU  - Liu X
AD  - Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, 
      1035 Boshuo Rd., Changchun, Jilin 130117, China.
AD  - The '973' National Basic Research Program of China, Changchun University of 
      Chinese Medicine, 1035 Boshuo Rd., Changchun, Jilin 130117, China.
FAU - Wang, Fuchun
AU  - Wang F
AD  - Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, 
      1035 Boshuo Rd., Changchun, Jilin 130117, China.
AD  - The '973' National Basic Research Program of China, Changchun University of 
      Chinese Medicine, 1035 Boshuo Rd., Changchun, Jilin 130117, China.
FAU - Tian, Jingyan
AU  - Tian J
AUID- ORCID: 0000-0001-8463-5262
AD  - Department of Urology, Second Division of The First Hospital of Jilin University, 
      3302 Jilin Rd., Changchun, Jilin 130031, China.
FAU - Wu, Hao
AU  - Wu H
AUID- ORCID: 0000-0001-5738-4015
AD  - Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang 
      St., Changchun, Jilin 130041, China.
AD  - The '973' National Basic Research Program of China, Changchun University of 
      Chinese Medicine, 1035 Boshuo Rd., Changchun, Jilin 130117, China.
LA  - eng
PT  - Journal Article
DEP - 20170618
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Reactive Oxygen Species)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Blotting, Western
MH  - Catechin/*analogs & derivatives/therapeutic use
MH  - Diabetes Complications/drug therapy
MH  - Diabetes Mellitus, Experimental
MH  - Endoplasmic Reticulum Stress/drug effects
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-E2-Related Factor 2/genetics/*metabolism
MH  - Oxidation-Reduction/drug effects
MH  - Oxidative Stress/drug effects
MH  - Reactive Oxygen Species
MH  - Testis/drug effects/*metabolism
PMC - PMC5494108
EDAT- 2017/07/13 06:00
MHDA- 2018/05/08 06:00
PMCR- 2017/06/18
CRDT- 2017/07/13 06:00
PHST- 2017/01/25 00:00 [received]
PHST- 2017/03/15 00:00 [revised]
PHST- 2017/04/06 00:00 [accepted]
PHST- 2017/07/13 06:00 [entrez]
PHST- 2017/07/13 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/06/18 00:00 [pmc-release]
AID - 10.1155/2017/3172692 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2017;2017:3172692. doi: 10.1155/2017/3172692. Epub 2017 Jun 
      18.