PMID- 28699511
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20180816
IS  - 1875-5550 (Electronic)
IS  - 1389-2037 (Linking)
VI  - 18
IP  - 11
DP  - 2017 Aug 30
TI  - Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of 
      Depressive Disorders.
PG  - 1152-1162
LID - 10.2174/1389203718666170710121532 [doi]
AB  - Striatal-enriched tyrosine protein phosphatase (STEP) is expressed mainly in the 
      brain. Its dysregulation is associated with Alzheimer's and Huntington's 
      diseases, schizophrenia, fragile X syndrome, drug abuse and stroke/ischemia. 
      However, an association between STEP and depressive disorders is still obscure. 
      The review discusses the theoretical foundations and experimental facts 
      concerning possible relationship between STEP dysregulation and depression risk. 
      STEP dephosphorylates and inactivates several key neuronal signaling proteins 
      such as extracellular signal-regulating kinase 1 and 2 (ERK1/2), stress activated 
      protein kinases p38, the Src family tyrosine kinases Fyn, Pyk2, NMDA and AMPA 
      glutamate receptors. The inactivation of these proteins decreases the expression 
      of brain derived neurotrophic factor (BDNF) necessary for neurogenesis and 
      neuronal survival. The deficit of BDNF results in progressive degeneration of 
      neurons in the hippocampus and cortex and increases depression risk. At the same 
      time, a STEP inhibitor, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine 
      hydrochloride (TC-2153), increases BDNF expression in the hippocampus and 
      attenuated the depressivelike behavior in mice. Thus, STEP is involved in the 
      mechanism of depressive disorders and it is a promising molecular target for 
      atypical antidepressant drugs of new generation.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Kulikova, Elizabeth
AU  - Kulikova E
AD  - Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of 
      Russian Academy of Sciences, 630090, Novosibirsk. Russian Federation.
FAU - Kulikov, Alexander
AU  - Kulikov A
AD  - Federal Research Center Institute of Cytology and Genetics, Siberian Branch of 
      Russian Academy of Sciences, 10 avenue Lavrentyev, 630090, Novosibirsk. Russian 
      Federation.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Protein Pept Sci
JT  - Current protein & peptide science
JID - 100960529
RN  - 0 (8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine)
RN  - 0 (Benzothiepins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.10.2 (FYN protein, human)
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
RN  - EC 3.1.3.48 (PTPN5 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases, Non-Receptor)
SB  - IM
MH  - Animals
MH  - Benzothiepins/pharmacology
MH  - Brain/drug effects/*enzymology/pathology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Depression/drug therapy/enzymology/*genetics/physiopathology
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - Neurons/drug effects/*enzymology/pathology
MH  - Phosphorylation
MH  - Protein Kinases/genetics/metabolism
MH  - Protein Tyrosine Phosphatases, Non-Receptor/antagonists & 
      inhibitors/*genetics/metabolism
MH  - Proto-Oncogene Proteins c-fyn/genetics/metabolism
MH  - Receptors, AMPA/genetics/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/genetics/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - BDNF
OT  - NMDA receptors.
OT  - STEP
OT  - TC-2153
OT  - antidepressant
OT  - depression
OT  - serotonin
EDAT- 2017/07/13 06:00
MHDA- 2017/11/07 06:00
CRDT- 2017/07/13 06:00
PHST- 2017/05/07 00:00 [received]
PHST- 2017/06/21 00:00 [revised]
PHST- 2017/06/21 00:00 [accepted]
PHST- 2017/07/13 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2017/07/13 06:00 [entrez]
AID - CPPS-EPUB-84637 [pii]
AID - 10.2174/1389203718666170710121532 [doi]
PST - ppublish
SO  - Curr Protein Pept Sci. 2017 Aug 30;18(11):1152-1162. doi: 
      10.2174/1389203718666170710121532.