PMID- 28699856
OWN - NLM
STAT- MEDLINE
DCOM- 20170921
LR  - 20191209
IS  - 1465-2099 (Electronic)
IS  - 0022-1317 (Linking)
VI  - 98
IP  - 7
DP  - 2017 Jul
TI  - Analysis of the origin of inherited chromosomally integrated human herpesvirus 6 
      in the Japanese population.
PG  - 1823-1830
LID - 10.1099/jgv.0.000834 [doi]
AB  - Integration of the complete human herpesvirus 6 (HHV-6) genome into the telomere 
      of a chromosome has been reported in some individuals (inherited chromosomally 
      integrated HHV-6; iciHHV-6). Since the proportion of iciHHV-6-positive 
      individuals with integration in chromosome 22 is high in Japan, we hypothesized a 
      founder effect. In this study, we sought to elucidate the reason for the high 
      proportion of viral integrations into chromosome 22. We analyzed six cases of 
      iciHHV-6A and two cases of iciHHV-6B, including one iciHHV-6A case with a matched 
      sample from a father and one iciHHV-6B case with a matched sample from a mother. 
      In iciHHV-6A, the same copy numbers of viral telomeric repeat sequences (TRS) and 
      the same five microsatellite markers were detected in both the index case and 
      paternal sample. Moreover, the same five microsatellite markers were demonstrated 
      in four cases and the same copy numbers of viral TRS were demonstrated in two 
      pairs of two cases. The present microsatellite analysis suggested that the viral 
      genomes detected in some iciHHV-6A patients were derived from a common ancestral 
      integration.
FAU - Kawamura, Yoshiki
AU  - Kawamura Y
AD  - Department of Pediatrics, Fujita Health University School of Medicine, 1-98 
      Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
AD  - Present address: Division of Viral Products, Office of Vaccines Research and 
      Review, Center for Biologics Evaluation and Research, Food and Drug 
      Administration, 1090340 New Hampshire Avenue, Silver Spring, MD 20993, USA.
FAU - Ohye, Tamae
AU  - Ohye T
AD  - Division of Molecular Genetics, Institute for Comprehensive Medical Science, 
      Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 
      470-1192, Japan.
AD  - Department of Molecular Laboratory Medicine, Faculty of Medical Technology, 
      Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 
      470-1192, Japan.
FAU - Miura, Hiroki
AU  - Miura H
AD  - Department of Pediatrics, Fujita Health University School of Medicine, 1-98 
      Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
FAU - Ihira, Masaru
AU  - Ihira M
AD  - Faculty of Clinical Engineering, Fujita Health University School of Health 
      Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
FAU - Kato, Yuri
AU  - Kato Y
AD  - Department of Clinical Laboratory, Fujita Health University Hospital, 1-98 
      Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
FAU - Kurahashi, Hiroki
AU  - Kurahashi H
AD  - Division of Molecular Genetics, Institute for Comprehensive Medical Science, 
      Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 
      470-1192, Japan.
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
AD  - Department of Pediatrics, Fujita Health University School of Medicine, 1-98 
      Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 22/genetics/*virology
MH  - Female
MH  - Genome, Viral
MH  - Herpesvirus 6, Human/classification/genetics/*isolation & purification/physiology
MH  - Humans
MH  - Japan
MH  - Male
MH  - Repetitive Sequences, Nucleic Acid
MH  - Roseolovirus Infections/congenital/genetics/*virology
MH  - Virus Integration
EDAT- 2017/07/13 06:00
MHDA- 2017/09/22 06:00
CRDT- 2017/07/13 06:00
PHST- 2017/07/13 06:00 [pubmed]
PHST- 2017/09/22 06:00 [medline]
PHST- 2017/07/13 06:00 [entrez]
AID - 10.1099/jgv.0.000834 [doi]
PST - ppublish
SO  - J Gen Virol. 2017 Jul;98(7):1823-1830. doi: 10.1099/jgv.0.000834. Epub 2017 Jul 
      12.