PMID- 28700564
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20181113
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 82
IP  - 5
DP  - 2017 Nov
TI  - Long-term effects of adenotonsillectomy on serum-specific immunoglobulin E.
PG  - 801-805
LID - 10.1038/pr.2017.165 [doi]
AB  - BackgroundThe biased immune reactions of the adenotonsillar tissues are not 
      always reflected by the serum immunoglobulin E (IgE); thus, we hypothesize that 
      the systemic atopic status may not be changed after the adenotonsillectomy (AT) 
      in children.MethodsTwenty-five children with AT and 23 age-matched healthy 
      children were enrolled into this study, and followed up for ~4 years. Nasal 
      Symptoms Scores (NSS), Quality of Life Scores (QOLS), specific IgE (sIgE), 
      cytokines, and inflammatory cell were documented in all the subjects before and 
      after study.ResultsFourteen patients and three healthy controls had positive 
      serum sIgE levels (>0.35 kU/l) at the study-start that was not changed by the 
      study-end. Two patients and two sIgE-negative healthy controls showed the 
      Dermatophagoidespteronyssinus sensitization at the study-end. NSS and QOLS showed 
      significant improvement after the surgery in the sIgE-positive patients (P<0.05), 
      whereas no significant changes were found in the sIgE-negative patients (P=1.00). 
      In addition, the serum sIgE-negative patients showed significant increases in 
      interleukin (IL)-4, IL-5, and IL-10 levels in the serum (P<0.001), although no 
      significant differences were found post surgery (P=0.667, 0.408, and 0.714, 
      respectively).ConclusionsOur study showed that AT did not affect the pediatric 
      atopic status. The systemic atopy may be independent of the tonsillar and adenoid 
      tissues in children.
FAU - Song, Lijuan
AU  - Song L
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Guo, Jinfei
AU  - Guo J
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Liao, Wenjing
AU  - Liao W
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Ye, Peichang
AU  - Ye P
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Liu, Li
AU  - Liu L
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Chen, Tao
AU  - Chen T
AD  - Department of Oncology, The First Affiliated Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Yang, Pingchang
AU  - Yang P
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Zhong, Nanshan
AU  - Zhong N
AD  - State Key Laboratory of Respiratory Disease, National Clinical Research Center 
      for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Sun, Baoqing
AU  - Sun B
AD  - Department of Allergy and Clinical Immunology, State Key Laboratory of 
      Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Zhang, Xiaowen
AU  - Zhang X
AD  - State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head 
      and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170802
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL4 protein, human)
RN  - 0 (IL5 protein, human)
RN  - 0 (Interleukin-5)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Adenoidectomy
MH  - Antigens, Dermatophagoides/administration & dosage/immunology
MH  - Arthropod Proteins/administration & dosage/immunology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood/diagnosis/immunology/prevention & control
MH  - Immunization
MH  - Immunoglobulin E/*blood
MH  - Inflammation/blood/immunology
MH  - Interleukin-10/blood
MH  - Interleukin-4/blood
MH  - Interleukin-5/blood
MH  - Male
MH  - Time Factors
MH  - *Tonsillectomy
MH  - Treatment Outcome
EDAT- 2017/07/13 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/07/13 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/05/12 00:00 [accepted]
PHST- 2017/07/13 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/07/13 06:00 [entrez]
AID - pr2017165 [pii]
AID - 10.1038/pr.2017.165 [doi]
PST - ppublish
SO  - Pediatr Res. 2017 Nov;82(5):801-805. doi: 10.1038/pr.2017.165. Epub 2017 Aug 2.