PMID- 28701670
OWN - NLM
STAT- MEDLINE
DCOM- 20170810
LR  - 20170810
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 58
IP  - 4
DP  - 2017 Aug 3
TI  - Impact of Compound Hypertonic Saline Solution on Decompensated Heart Failure.
PG  - 601-607
LID - 10.1536/ihj.16-313 [doi]
AB  - The aim of the present study was to evaluate the effects of hypertonic saline 
      solution (C-HSS) with high dose furosemide on hospitalization time, readmission, 
      and mortality in patients with New York Heart Association (NYHA) class III heart 
      failure.Decompensated heart failure patients (NYHA III) with chronic ischemic or 
      nonischemic cardiomyopathy and ejection fraction < 40% were divided into 2 groups 
      in an open-label random manner: the first group received a 1-hour intravenous 
      infusion of furosemide (100 mg) plus compound C-HSS (100 mL) twice daily and 
      underwent serious water restriction (500 mL/day); the second group received 
      furosemide intravenous bolus (100 mg) twice a day and water restriction (500 
      mL/day), without C-HSS. Both groups had normal sodium (120 mmol sodium) intake. 
      After discharge, the two groups continued to receive 120 mmol Na/day and 500-1000 
      mL water/day.The first group (132 C-HSS patients) had an increase in urination, a 
      reduction in hospitalization time (4 +/- 2 versus 7 +/- 2 days, P < 0.01), and a 
      reduction in hospitalization costs (2210 RMB versus 3506 RMB, P < 0.01) compared 
      with the second group (132 without C-HSS patients). During the follow-up period 
      (36 +/- 12 months), the first group had a significantly higher average readmission 
      time (31.84 +/- 7.58 months versus 15.60 +/- 6.25 months, P < 0.01) and lower 
      mortality rate (16.5% versus 31.9%, P < 0.01).The results suggest that periodical 
      C-HSS administration, combined with serious water restriction and a normal sodium 
      diet, significantly reduces the hospitalization time, readmission rate, and 
      mortality in patients with NYHA class III HF.
FAU - Wan, Yanfang
AU  - Wan Y
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Li, Lei
AU  - Li L
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Niu, Heping
AU  - Niu H
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Ma, Xiaoli
AU  - Ma X
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Yuan, Chen
AU  - Yuan C
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Mu, Guichen
AU  - Mu G
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170713
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Diuretics)
RN  - 0 (Saline Solution, Hypertonic)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - China/epidemiology
MH  - Diuretics/administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Female
MH  - Follow-Up Studies
MH  - Furosemide/*administration & dosage
MH  - Heart Failure/*drug therapy/mortality/physiopathology
MH  - Hospital Mortality/trends
MH  - Hospitalization/trends
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Saline Solution, Hypertonic/*administration & dosage
MH  - Stroke Volume/*physiology
MH  - Survival Rate/trends
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Diuretic
OT  - Electrolytes
OT  - Furosemide
OT  - Sodium
EDAT- 2017/07/14 06:00
MHDA- 2017/08/11 06:00
CRDT- 2017/07/14 06:00
PHST- 2017/07/14 06:00 [pubmed]
PHST- 2017/08/11 06:00 [medline]
PHST- 2017/07/14 06:00 [entrez]
AID - 10.1536/ihj.16-313 [doi]
PST - ppublish
SO  - Int Heart J. 2017 Aug 3;58(4):601-607. doi: 10.1536/ihj.16-313. Epub 2017 Jul 13.