PMID- 28701932
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 11
DP  - 2017
TI  - Functional Connectivity Differences in the Insular Sub-regions in Migraine 
      without Aura: A Resting-State Functional Magnetic Resonance Imaging Study.
PG  - 124
LID - 10.3389/fnbeh.2017.00124 [doi]
LID - 124
AB  - Objective: The objective of this study was to investigate resting-state 
      functional connectivity (FC) differences in insular sub-regions during the 
      interictal phase in patients with migraine without aura (MWoA). Methods: 
      Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control 
      group) were recruited for this study. All of the subjects underwent neurological 
      examination and magnetic resonance imaging (MRI). The MRI data were processed 
      using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 
      software to obtain the FC z-score of the sub-regions of both insulas (six 
      sub-regions on each side). Therefore, there were a total of 12 regions of 
      interest (ROIs) that were used as seed points for the statistical analysis. 
      Results: There was abnormal FC between the insular sub-regions and multiple brain 
      regions in the MWoA patients compared with the healthy control group, and a clear 
      laterality was also observed. In addition, the FC z-score of certain sub-regions 
      was negatively correlated with the disease duration. Conclusion: Different 
      insular sub-regions are functionally associated with different regions of the 
      brain and therefore have different functions. In MWoA, the FC between the insular 
      sub-regions and other brain regions was mostly reduced, while a small amount was 
      increased; additionally, the FC may be ipsilateral with a right-side advantage. 
      Variations in the FC of insular sub-regions can be observed as an important 
      indicator of MWoA.
FAU - Yu, Zhi-Bo
AU  - Yu ZB
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
AD  - Department of Medical Imaging, PLA No.324 HospitalChongqing, China.
FAU - Lv, Yan-Bing
AU  - Lv YB
AD  - Department of General Surgery, PLA No.324 HospitalChongqing, China.
FAU - Song, Ling-Heng
AU  - Song LH
AD  - Department of Medical Imaging, PLA No.324 HospitalChongqing, China.
FAU - Liu, Dai-Hong
AU  - Liu DH
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Huang, Xue-Ling
AU  - Huang XL
AD  - Department of Nursing, Chongqing Three Gorges Medical CollegeChongqing, China.
FAU - Hu, Xin-Yue
AU  - Hu XY
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Zuo, Zhi-Wei
AU  - Zuo ZW
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Yang, Qian
AU  - Yang Q
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Peng, Jing
AU  - Peng J
AD  - Department of Neurology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Zhou, Zhen-Hua
AU  - Zhou ZH
AD  - Department of Neurology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
FAU - Li, Hai-Tao
AU  - Li HT
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      UniversityChongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC5487515
OTO - NOTNLM
OT  - brain function
OT  - functional connectivity (FC)
OT  - functional magnetic resonance imaging (fMRI)
OT  - insula
OT  - migraine without aura (MWoA)
OT  - pain
EDAT- 2017/07/14 06:00
MHDA- 2017/07/14 06:01
PMCR- 2017/01/01
CRDT- 2017/07/14 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2017/06/13 00:00 [accepted]
PHST- 2017/07/14 06:00 [entrez]
PHST- 2017/07/14 06:00 [pubmed]
PHST- 2017/07/14 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2017.00124 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2017 Jun 28;11:124. doi: 10.3389/fnbeh.2017.00124. 
      eCollection 2017.