PMID- 28703772
OWN - NLM
STAT- MEDLINE
DCOM- 20180510
LR  - 20181202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 7
DP  - 2017 Jul 13
TI  - Understanding the Inguinal Sinus in Sheep (Ovis aries)-Morphology, Secretion, and 
      Expression of Progesterone, Estrogens, and Prolactin Receptors.
LID - 10.3390/ijms18071516 [doi]
LID - 1516
AB  - Post-parturient behavior of mammalian females is essential for early 
      parent-offspring contact. After delivery, lambs need to ingest colostrum for 
      obtaining the related immunological protection, and early interactions between 
      the mother and the lamb are crucial. Despite visual and auditory cues, olfactory 
      cues are decisive in lamb orientation to the mammary gland. In sheep, the 
      inguinal sinus is located bilaterally near the mammary gland as a skin pouch 
      (IGS) that presents a gland that secretes a strong-smelling wax. Sheep IGS gland 
      functions have many aspects under evaluation. The objective of the present study 
      was to evaluate sheep IGS gland functional aspects and mRNA transcription and the 
      protein expression of several hormone receptors, such as progesterone receptor 
      (PGR), estrogen receptor 1 (ESR1), and 2 (ESR2) and prolactin receptor (PRLR) 
      present. In addition, another aim was to achieve information about IGS 
      ultrastructure and chemical compounds produced in this gland. All hormone 
      receptors evaluated show expression in IGS during the estrous cycle 
      (follicular/luteal phases), pregnancy, and the post-partum period. IGS secretion 
      is rich in triterpenoids that totally differ from the surrounding skin. They 
      might be essential substances for the development of an olfactory preference of 
      newborns to their mothers.
FAU - Alexandre-Pires, Graca
AU  - Alexandre-Pires G
AD  - CIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. 
      Universidade Tecnica, 1300-477 Lisboa, Portugal. gpires@fmv.ulisboa.pt.
FAU - Martins, Catarina
AU  - Martins C
AD  - CEDOC-Chronic Diseases Research Center, Immunology, NOVA Medical School, 
      Universidade Nova de Lisboa, Rua Camara Pestana n degrees  6, 6-A Edificio CEDOC II, 
      1150-082 Lisboa, Portugal. catarina.martins@fcm.unl.pt.
FAU - Galvao, Antonio M
AU  - Galvao AM
AD  - CIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. 
      Universidade Tecnica, 1300-477 Lisboa, Portugal. agalvao@fmv.ulisboa.pt.
FAU - Miranda, Margarida
AU  - Miranda M
AD  - iMed.ULisboa, Pharmacological and Regulatory Sciences Group, Faculty of Pharmacy, 
      Universidade de Lisboa, Av. Gama Pinto, 1649-003 Lisbon, Portugal. 
      mimiranda@live.com.pt.
FAU - Silva, Olga
AU  - Silva O
AD  - iMed.ULisboa, Pharmacological and Regulatory Sciences Group, Faculty of Pharmacy, 
      Universidade de Lisboa, Av. Gama Pinto, 1649-003 Lisbon, Portugal. 
      odsilva@campus.ul.pt.
FAU - Ligeiro, Dario
AU  - Ligeiro D
AD  - Centro de Sangue e Transplantacao de Lisboa, IPST,IP Alameda das Linhas de Torres 
      117, 1749-005 Lisbon, Portugal. dario@ipst.min-saude.pt.
FAU - Nunes, Telmo
AU  - Nunes T
AD  - Microscopy Center, Faculty of Sciences, Campo Grande, 1749-016 Lisboa, Portugal. 
      telmonunes@hotmail.com.
FAU - Ferreira-Dias, Graca
AU  - Ferreira-Dias G
AD  - CIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. 
      Universidade Tecnica, 1300-477 Lisboa, Portugal. gmlfdias@fmv.ulisboa.pt.
LA  - eng
PT  - Journal Article
DEP - 20170713
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Prolactin)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Estrogens/*metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Mammary Glands, Animal/*anatomy & histology/cytology/*metabolism/ultrastructure
MH  - Pregnancy
MH  - Progesterone/*metabolism
MH  - Receptors, Prolactin/*metabolism
MH  - Sheep
PMC - PMC5536006
OTO - NOTNLM
OT  - ESR1
OT  - ESR2
OT  - PGR
OT  - PRLR
OT  - chemical compounds
OT  - inguinal sinus
OT  - morphology
OT  - transcription
OT  - triterpenoids
COIS- The authors declare no conflict of interest.
EDAT- 2017/07/14 06:00
MHDA- 2018/05/11 06:00
PMCR- 2017/07/01
CRDT- 2017/07/14 06:00
PHST- 2017/05/01 00:00 [received]
PHST- 2017/07/10 00:00 [revised]
PHST- 2017/07/10 00:00 [accepted]
PHST- 2017/07/14 06:00 [entrez]
PHST- 2017/07/14 06:00 [pubmed]
PHST- 2018/05/11 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - ijms18071516 [pii]
AID - ijms-18-01516 [pii]
AID - 10.3390/ijms18071516 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Jul 13;18(7):1516. doi: 10.3390/ijms18071516.