PMID- 28704274
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20181106
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 28
IP  - 7
DP  - 2017 Oct
TI  - Maternal separation induces long-term effects on monoamines and brain-derived 
      neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: 
      differential effects after a stress challenge.
PG  - 545-557
LID - 10.1097/FBP.0000000000000324 [doi]
AB  - The maternal separation (MS) paradigm is a well-known animal model that resembles 
      the stress of early adverse life experiences and produces structural and 
      functional abnormalities when animals are adults. The present study analyzed the 
      effect of MS, in adult mice, on brain-derived neurotrophic factor (BDNF), 
      serotonin (5-HT), and dopamine (DA) levels, and the turnover rate in the 
      hippocampus, frontal cortex, and amygdala, and brain regions that are associated 
      with emotion. Also, the effects of MS in depression-like responses in adult mice 
      were studied. The results showed that MS from postnatal day 8-21 induces 
      depression-like behaviors. In MS mice, the three brain areas showed differential 
      responses in 5-HT, DA, and BDNF concentrations both in basal levels and when 
      animals were challenged with an acute stressor in adulthood. Specifically, under 
      basal conditions, MS increased monoamine and BDNF levels in the hippocampus and 
      amygdala, but decreased these levels in the frontal cortex. In MS, but not in 
      control mice, the amygdala responded to the stress challenge, whereas the frontal 
      cortex showed no response. Finally, the hippocampus showed increased 5-HT and DA 
      activity, but not increased BDNF after the stress challenge in MS mice. The 
      present results support the theory of the hypofunctionality of the frontal cortex 
      and hyperactivity of mesolimbic areas in depression-like conditions.
FAU - Recamier-Carballo, Soledad
AU  - Recamier-Carballo S
AD  - aDepartment of Pharmacobiology, Centre for Research and Advance Studies 
      (Cinvestav-Coapa) bLaboratory of Psychopharmacology, Neuroscience, National 
      Institute Of Psychiatry 'Ramon de la Fuente Muniz', Mexico D.F., Mexico.
FAU - Estrada-Camarena, Erika
AU  - Estrada-Camarena E
FAU - Lopez-Rubalcava, Carolina
AU  - Lopez-Rubalcava C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amygdala/drug effects/metabolism
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Biogenic Monoamines/metabolism
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/metabolism
MH  - Dopamine/metabolism
MH  - Female
MH  - Frontal Lobe/drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - *Maternal Deprivation
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Serotonin/metabolism
MH  - Stress, Psychological/*metabolism/physiopathology
EDAT- 2017/07/14 06:00
MHDA- 2018/04/17 06:00
CRDT- 2017/07/14 06:00
PHST- 2017/07/14 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2017/07/14 06:00 [entrez]
AID - 10.1097/FBP.0000000000000324 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2017 Oct;28(7):545-557. doi: 10.1097/FBP.0000000000000324.