PMID- 28704672 OWN - NLM STAT- MEDLINE DCOM- 20180810 LR - 20200306 IS - 1879-1026 (Electronic) IS - 0048-9697 (Print) IS - 0048-9697 (Linking) VI - 607-608 DP - 2017 Dec 31 TI - Anthropometric measures at birth and early childhood are associated with neurodevelopmental outcomes among Bangladeshi children aged 2-3years. PG - 475-482 LID - S0048-9697(17)31586-3 [pii] LID - 10.1016/j.scitotenv.2017.06.168 [doi] AB - Among a cohort of children located in rural areas of Bangladesh affected by high levels of exposure to environmental metals, we investigated the associations between anthropometric measures, growth trajectory, and neurodevelopment at age 20-40months. Our study population included mothers and their children who participated in a longitudinal birth cohort study that took in place in the Pabna and Sirajdikhan areas of Bangladesh. Anthropometric measures including weight, length, and head circumference were measured at birth, age 12months, and age 20-40months. Neurodevelopment was assessed using Bayley Scales of Infant and Toddler Development Third Edition (BSID-III) multi-scale at age 20-40months. A total of 777 mother-child pairs were included. Higher anthropometric measures at 20-40months were associated with higher cognitive, language, and motor scores on BSID-III. For example, a 1-kg increment in birthweight was associated with an increase of 2.11 for cognitive score (p<0.0001), 1.63 for language score (p=0.006), and 0.89 for motor scores (p=0.03). Greater positive changes in growth parameters, or growth trajectory, between birth and 20-40months were also associated with higher BSID-III scores. These associations remained significant after adjusting for potential confounders and prenatal exposure to environmental metals. These findings suggest that even when taking into account high environmental metal exposures, prenatal and early childhood growth have strong associations with neurodevelopmental test scores in early childhood. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Lee, Jane J AU - Lee JJ AD - Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. Electronic address: jane.lee2@childrens.harvard.edu. FAU - Kapur, Kush AU - Kapur K AD - Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: kush.kapur@childrens.harvard.edu. FAU - Rodrigues, Ema G AU - Rodrigues EG AD - Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. Electronic address: emarod77@yahoo.com. FAU - Ibne Hasan, Md Omar Sharif AU - Ibne Hasan MOS AD - Dhaka Community Hospital, 190/1, Wireless Railgate Bara Moghbazar, Dhaka, 1217, Bangladesh. Electronic address: dr.sharif0909@gmail.com. FAU - Quamruzzaman, Quazi AU - Quamruzzaman Q AD - Dhaka Community Hospital, 190/1, Wireless Railgate Bara Moghbazar, Dhaka, 1217, Bangladesh. Electronic address: qqz@bangla.net. FAU - Wright, Robert O AU - Wright RO AD - Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, NY, New York, 10029, USA. Electronic address: robert.wright@mssm.edu. FAU - Bellinger, David C AU - Bellinger DC AD - Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. Electronic address: david.bellinger@childrens.harvard.edu. FAU - Christiani, David C AU - Christiani DC AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. Electronic address: dchris@hsph.harvard.edu. FAU - Mazumdar, Maitreyi AU - Mazumdar M AD - Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. Electronic address: maitreyi.mazumdarmdmph@childrens.harvard.edu. LA - eng GR - P30 ES000002/ES/NIEHS NIH HHS/United States GR - R01 ES026317/ES/NIEHS NIH HHS/United States GR - U54 HD090255/HD/NICHD NIH HHS/United States GR - K23 ES017437/ES/NIEHS NIH HHS/United States GR - P42 ES016454/ES/NIEHS NIH HHS/United States GR - R01 ES011622/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20170727 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Metals, Heavy) SB - IM MH - *Anthropometry MH - Bangladesh MH - Birth Weight MH - *Child Development MH - Child, Preschool MH - Environmental Exposure/*analysis MH - Humans MH - Infant MH - Infant, Newborn MH - Language Development MH - Longitudinal Studies MH - Metals, Heavy/*analysis MH - Motor Skills PMC - PMC5587388 MID - NIHMS891958 OTO - NOTNLM OT - Anthropometric measurements OT - Bangladesh OT - Bayley Scales of Infant Development OT - Environmental chemicals OT - Neurodevelopmental status COIS- Disclosures: The authors have no conflicts of interest relevant to this article to disclose. EDAT- 2017/07/14 06:00 MHDA- 2018/08/11 06:00 PMCR- 2018/12/31 CRDT- 2017/07/14 06:00 PHST- 2017/04/01 00:00 [received] PHST- 2017/06/20 00:00 [revised] PHST- 2017/06/20 00:00 [accepted] PHST- 2017/07/14 06:00 [pubmed] PHST- 2018/08/11 06:00 [medline] PHST- 2017/07/14 06:00 [entrez] PHST- 2018/12/31 00:00 [pmc-release] AID - S0048-9697(17)31586-3 [pii] AID - 10.1016/j.scitotenv.2017.06.168 [doi] PST - ppublish SO - Sci Total Environ. 2017 Dec 31;607-608:475-482. doi: 10.1016/j.scitotenv.2017.06.168. Epub 2017 Jul 27.