PMID- 28705305
OWN - NLM
STAT- MEDLINE
DCOM- 20171027
LR  - 20221207
IS  - 2212-5353 (Electronic)
IS  - 2212-5345 (Linking)
VI  - 55
IP  - 4
DP  - 2017 Jul
TI  - Clinical characteristics of Japanese candidates for lung transplant for 
      interstitial lung disease and risk factors for early death while on the waiting 
      list.
PG  - 264-269
LID - S2212-5345(17)30056-4 [pii]
LID - 10.1016/j.resinv.2017.03.002 [doi]
AB  - BACKGROUND: Lung transplants have produced very favorable outcomes for patients 
      with interstitial lung disease (ILD) in Japan. However, because of the severe 
      donor lung shortage, patients must wait approximately 2.5 years before they can 
      undergo transplantation and many candidates die before allocation. We reveal the 
      clinical characteristics of Japanese patients with ILD who are candidates for 
      lung transplants and the risk factors for early death while on the waiting list. 
      METHODS: We retrospectively reviewed the clinical data of patients registered in 
      the Japan Organ Transplant Network from Okayama University Hospital who are 
      candidates for cadaveric lung transplants for ILD between 1999 and 2015. RESULTS: 
      Fifty-three patients with ILD were included (24 patients with idiopathic 
      pulmonary fibrosis and 29 others). They had severe pulmonary dysfunction and low 
      exercise tolerability. The median waiting time for transplantation was 462 days, 
      and 22 patients died before allocation. Patients who died before 462 days without 
      undergoing transplantation had more severe dyspnea, shorter 6-minute walk 
      distance (6MWD), and lower performance status than those who waited >/=462 days. 
      CONCLUSIONS: Japanese candidates for cadaveric lung transplants for ILD have 
      severe pulmonary dysfunction. Severe dyspnea, short 6MWD, and low performance 
      status are risk factors for early death while on the waiting list.
CI  - Copyright (c) 2017 The Japanese Respiratory Society. Published by Elsevier B.V. All 
      rights reserved.
FAU - Higo, Hisao
AU  - Higo H
AD  - Department of Hematology, Oncology and Respiratory Medicine, Okayama University 
      Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 
      Japan.
FAU - Kurosaki, Takeshi
AU  - Kurosaki T
AD  - Department of Organ Transplant Center, Okayama University Hospital, Okayama, 
      Japan.
FAU - Ichihara, Eiki
AU  - Ichihara E
AD  - Department of Hematology, Oncology and Respiratory Medicine, Okayama University 
      Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 
      Japan.
FAU - Kubo, Toshio
AU  - Kubo T
AD  - Center for Clinical Oncology, Okayama University Hospital, Okayama, Japan.
FAU - Miyoshi, Kentaroh
AU  - Miyoshi K
AD  - Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
FAU - Otani, Shinji
AU  - Otani S
AD  - Department of Organ Transplant Center, Okayama University Hospital, Okayama, 
      Japan.
FAU - Sugimoto, Seiichiro
AU  - Sugimoto S
AD  - Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
FAU - Yamane, Masaomi
AU  - Yamane M
AD  - Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
FAU - Miyahara, Nobuaki
AU  - Miyahara N
AD  - Department of Medical Technology, Okayama University Graduate School of Health 
      Sciences, Okayama, Japan.
FAU - Kiura, Katsuyuki
AU  - Kiura K
AD  - Department of Respiratory and Allergy Medicine, Okayama University Hospital, 
      Okayama, Japan.
FAU - Miyoshi, Shinichiro
AU  - Miyoshi S
AD  - Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
FAU - Oto, Takahiro
AU  - Oto T
AD  - Department of Organ Transplant Center, Okayama University Hospital, Okayama, 
      Japan. Electronic address: oto@md.okayama-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20170622
PL  - Netherlands
TA  - Respir Investig
JT  - Respiratory investigation
JID - 101581124
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Dyspnea
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Lung Diseases, Interstitial/*mortality/physiopathology/*surgery
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Risk Factors
MH  - Severity of Illness Index
MH  - Survival Rate
MH  - Time Factors
MH  - Waiting Lists/*mortality
MH  - Walk Test
OTO - NOTNLM
OT  - Interstitial lung disease
OT  - Lung allocation system
OT  - Lung transplant
OT  - Performance status
EDAT- 2017/07/15 06:00
MHDA- 2017/10/28 06:00
CRDT- 2017/07/15 06:00
PHST- 2016/11/21 00:00 [received]
PHST- 2017/02/20 00:00 [revised]
PHST- 2017/03/01 00:00 [accepted]
PHST- 2017/07/15 06:00 [entrez]
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2017/10/28 06:00 [medline]
AID - S2212-5345(17)30056-4 [pii]
AID - 10.1016/j.resinv.2017.03.002 [doi]
PST - ppublish
SO  - Respir Investig. 2017 Jul;55(4):264-269. doi: 10.1016/j.resinv.2017.03.002. Epub 
      2017 Jun 22.