PMID- 28706188 OWN - NLM STAT- MEDLINE DCOM- 20190212 LR - 20231112 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 7 IP - 1 DP - 2017 Jul 13 TI - Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress. PG - 5277 LID - 10.1038/s41598-017-05440-8 [doi] LID - 5277 AB - Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience. FAU - Faraji, Jamshid AU - Faraji J AD - Golestan University of Medical Sciences, Faculty of Nursing & Midwifery, Gorgan, I. R. of Iran. jamshid.faraji@uleth.ca. AD - University of Lethbridge, Canadian Centre for Behavioural Neuroscience, Lethbridge, Canada. jamshid.faraji@uleth.ca. FAU - Soltanpour, Nabiollah AU - Soltanpour N AD - Babol University of Medical Sciences, Department of Anatomical Sciences, Babol, I. R. of Iran. FAU - Lotfi, Hamid AU - Lotfi H AD - Islamic Azad University, Department of Psychology, Tonekabon Branch, Tonekabon, I. R. of Iran. FAU - Moeeini, Reza AU - Moeeini R AD - Avicenna Institute of Neuroscience, Department of Behavioural Studies, Yazd, I. R. of Iran. FAU - Moharreri, Ali-Reza AU - Moharreri AR AD - Golestan University of Medical Sciences, Department of Anatomy, Gorgan, I. R. of Iran. FAU - Roudaki, Shabnam AU - Roudaki S AD - Avicenna Institute of Neuroscience, Department of Behavioural Studies, Yazd, I. R. of Iran. FAU - Hosseini, S Abedin AU - Hosseini SA AD - Golestan University of Medical Sciences, Faculty of Nursing & Midwifery, Gorgan, I. R. of Iran. FAU - Olson, David M AU - Olson DM AD - University of Alberta, Department of Obstetrics and Gynecology, Edmonton, Canada. FAU - Abdollahi, Ali-Akbar AU - Abdollahi AA AD - Golestan University of Medical Sciences, Faculty of Nursing & Midwifery, Gorgan, I. R. of Iran. FAU - Soltanpour, Nasrin AU - Soltanpour N AD - University of Lethbridge, Canadian Centre for Behavioural Neuroscience, Lethbridge, Canada. FAU - Mohajerani, Majid H AU - Mohajerani MH AD - University of Lethbridge, Canadian Centre for Behavioural Neuroscience, Lethbridge, Canada. FAU - Metz, Gerlinde A S AU - Metz GAS AUID- ORCID: 0000-0002-5801-7716 AD - University of Lethbridge, Canadian Centre for Behavioural Neuroscience, Lethbridge, Canada. LA - eng GR - 102652/CIHR/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170713 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Animals MH - *Behavior, Animal MH - Depression/*etiology MH - Female MH - Hippocampus/metabolism MH - *Inheritance Patterns MH - Rats MH - Rats, Wistar MH - *Social Isolation MH - *Social Support MH - Stress, Psychological/*complications PMC - PMC5509705 COIS- The authors declare that they have no competing interests. EDAT- 2017/07/15 06:00 MHDA- 2019/02/13 06:00 PMCR- 2017/07/13 CRDT- 2017/07/15 06:00 PHST- 2017/01/09 00:00 [received] PHST- 2017/05/30 00:00 [accepted] PHST- 2017/07/15 06:00 [entrez] PHST- 2017/07/15 06:00 [pubmed] PHST- 2019/02/13 06:00 [medline] PHST- 2017/07/13 00:00 [pmc-release] AID - 10.1038/s41598-017-05440-8 [pii] AID - 5440 [pii] AID - 10.1038/s41598-017-05440-8 [doi] PST - epublish SO - Sci Rep. 2017 Jul 13;7(1):5277. doi: 10.1038/s41598-017-05440-8.