PMID- 28706476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 11
DP  - 2017
TI  - Long-Term Sex-Dependent Vulnerability to Metabolic challenges in Prenatally 
      Stressed Rats.
PG  - 113
LID - 10.3389/fnbeh.2017.00113 [doi]
LID - 113
AB  - Prenatal stress (PNS) might affect the developmental programming of adult chronic 
      diseases such as metabolic and mood disorders. The molecular mechanisms 
      underlying such regulations may rely upon long-term changes in stress-responsive 
      effectors such as Brain-Derived Neurotrophic Factor (BDNF) that can affect 
      neuronal plasticity underlying mood disorders and may also play a role in 
      metabolic regulation. Based upon previous data, we hypothesized that PNS might 
      lead to greater vulnerability to an obesogenic challenge experienced at 
      adulthood. In order to investigate our hypothesis, pregnant Sprague-Dawley female 
      rats underwent a chronic procedure of restraint stress during the last week of 
      gestation. The adult offspring were then challenged with a high fat diet (HFD) 
      over 8 weeks and tested for metabolic and emotional endpoints. Moreover, brain 
      specific changes in Bdnf expression levels were also assessed. Overall, HFD 
      resulted in increased caloric intake, insulin resistance, impaired glucose 
      tolerance and higher circulating levels of leptin, while PNS increased the 
      leptin/adiponectin ratio, an index of metabolic risk in adult male subjects. 
      Interestingly, HFD consumption increased anxiety-like behaviors in the Elevated 
      Plus Maze, particularly in males, and this effect was buffered by PNS. Levels of 
      Bdnf were finely modulated by PNS and HFD in a region- and sex-dependent fashion: 
      female offspring overall showed greater plasticity, possibly mediated through 
      increased total Bdnf mRNA expression both in the hippocampus and in the 
      hypothalamus. In conclusion, while the experience of maternal stress during 
      intrauterine life promotes metabolic dysfunction induced by a HFD at adulthood, 
      the interaction between PNS and HFD is positive in male subjects, and in 
      agreement with the match-mismatch hypothesis, resulting in a reduction of anxious 
      behaviors.
FAU - Panetta, Pamela
AU  - Panetta P
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di 
      SanitaRome, Italy.
FAU - Berry, Alessandra
AU  - Berry A
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di 
      SanitaRome, Italy.
FAU - Bellisario, Veronica
AU  - Bellisario V
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di 
      SanitaRome, Italy.
FAU - Capoccia, Sara
AU  - Capoccia S
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di 
      SanitaRome, Italy.
FAU - Raggi, Carla
AU  - Raggi C
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di 
      SanitaRome, Italy.
FAU - Luoni, Alessia
AU  - Luoni A
AD  - Department of Pharmacological and Biomolecular Sciences, University of 
      MilanMilan, Italy.
FAU - Longo, Linda
AU  - Longo L
AD  - Department of Pharmacological and Biomolecular Sciences, University of 
      MilanMilan, Italy.
FAU - Riva, Marco A
AU  - Riva MA
AD  - Department of Pharmacological and Biomolecular Sciences, University of 
      MilanMilan, Italy.
FAU - Cirulli, Francesca
AU  - Cirulli F
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di 
      SanitaRome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170629
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC5489562
OTO - NOTNLM
OT  - Bdnf
OT  - adipokines
OT  - animal models
OT  - anxiety
OT  - high-fat diet
OT  - metabolism
OT  - prenatal stress
OT  - sex differences
EDAT- 2017/07/15 06:00
MHDA- 2017/07/15 06:01
PMCR- 2017/01/01
CRDT- 2017/07/15 06:00
PHST- 2017/01/27 00:00 [received]
PHST- 2017/05/26 00:00 [accepted]
PHST- 2017/07/15 06:00 [entrez]
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2017/07/15 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2017.00113 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2017 Jun 29;11:113. doi: 10.3389/fnbeh.2017.00113. 
      eCollection 2017.