PMID- 28706510
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 8
DP  - 2017
TI  - Natural Killer Cell Functions during the Innate Immune Response to Pathogenic 
      Streptococci.
PG  - 1196
LID - 10.3389/fmicb.2017.01196 [doi]
LID - 1196
AB  - Dendritic cells (DCs) and NK cells play a crucial role in the first phase of host 
      defense against infections. Group B Streptococcus (GBS) and Streptococcus suis 
      are encapsulated streptococci causing severe systemic inflammation, leading to 
      septicemia and meningitis. Yet, the involvement of NK cells in the innate immune 
      response to encapsulated bacterial infection is poorly characterized. Here, it 
      was observed that these two streptococcal species rapidly induce the release of 
      IFN-gamma and that NK cells are the major cell type responsible for this production 
      during the acute phase of the infection. Albeit S. suis capacity to activate NK 
      cells was lower than that of GBS, these cells partially contribute to S. suis 
      systemic infection; mainly through amplification of the inflammatory loop. In 
      contrast, such a role was not observed during GBS systemic infection. IFN-gamma 
      release by NK cells required the presence of DCs, which in turn had a synergistic 
      effect on DC cytokine production. These responses were mainly mediated by direct 
      DC-NK cell contact and partially dependent on soluble factors. Though IL-12 and 
      LFA-1 were shown to be critical in S. suis-mediated activation of the DC-NK cell 
      crosstalk, different or redundant molecular pathways modulate DC-NK interactions 
      during GBS infection. The bacterial capsular polysaccharides also differently 
      modulated NK cell activation. Together, these results demonstrated a role of NK 
      cells in the innate immune response against encapsulated streptococcal 
      infections; yet the molecular pathways governing NK activation seem to differ 
      upon the pathogen and should not be generalized when studying bacterial 
      infections.
FAU - Lemire, Paul
AU  - Lemire P
AD  - Laboratory of Immunology of the Swine and Poultry Infectious Diseases Research 
      Centre, Faculty of Veterinary Medicine, University of MontrealSt-Hyacinthe, QC, 
      Canada.
FAU - Galbas, Tristan
AU  - Galbas T
AD  - Laboratory of Molecular Immunology, Faculty of Medicine, University of 
      MontrealMontreal, QC, Canada.
FAU - Thibodeau, Jacques
AU  - Thibodeau J
AD  - Laboratory of Molecular Immunology, Faculty of Medicine, University of 
      MontrealMontreal, QC, Canada.
FAU - Segura, Mariela
AU  - Segura M
AD  - Laboratory of Immunology of the Swine and Poultry Infectious Diseases Research 
      Centre, Faculty of Veterinary Medicine, University of MontrealSt-Hyacinthe, QC, 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20170629
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC5489694
OTO - NOTNLM
OT  - Streptococcus suis
OT  - capsular polysaccharide
OT  - dendritic cells
OT  - group B Streptococcus
OT  - natural killer cells
EDAT- 2017/07/15 06:00
MHDA- 2017/07/15 06:01
PMCR- 2017/06/29
CRDT- 2017/07/15 06:00
PHST- 2017/03/01 00:00 [received]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/07/15 06:00 [entrez]
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2017/07/15 06:01 [medline]
PHST- 2017/06/29 00:00 [pmc-release]
AID - 10.3389/fmicb.2017.01196 [doi]
PST - epublish
SO  - Front Microbiol. 2017 Jun 29;8:1196. doi: 10.3389/fmicb.2017.01196. eCollection 
      2017.