PMID- 28706732
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210430
IS  - 2055-2238 (Print)
IS  - 2055-2238 (Electronic)
IS  - 2055-2238 (Linking)
VI  - 3
IP  - 2
DP  - 2017 Jun
TI  - Age increases MCP-1 level in association with bariatric surgery operating time 
      and metabolic risk severity.
PG  - 193-200
LID - 10.1002/osp4.105 [doi]
AB  - OBJECTIVE: Assess the role of inflammation on operating time in younger vs. older 
      bariatric surgery patients. METHODS: Fifty-five younger (F: 46, Age: 
      34.9 +/- 4.0 years, body mass index [BMI]: 48.2 +/- 1.0 kg m(-2)) and 48 older (F: 
      34, Age: 57.0 +/- 5.1 years, BMI: 46.8 +/- 1.0 kg m(-2)) adults were studied prior to 
      surgery. Blood pressure, glycaemic control (fasting glucose/insulin, HbA(1c)), 
      lipids (high-density lipoprotein and triglycerides) and inflammation (monocyte 
      chemoattractant protein-1 [MCP-1]) were assessed. Metabolic risk severity 
      z-scores were calculated from clinical outcomes. Omental adipose biopsies were 
      collected at surgery for MCP-1 protein analysis. Operating time was used to 
      characterize surgical difficulty. RESULTS: Older vs. younger adults had higher 
      HbA(1c) (P = 0.03). There was no difference in BMI, lipids, metabolic risk 
      severity or insulin between groups, but operating time was longer in older vs. 
      younger individuals (P = 0.04). Circulating MCP-1 was also elevated in older vs. 
      younger adults (P = 0.04) independent of HbA(1c), although this was not explained 
      by omental fat. Nevertheless, serum MCP-1 was associated with increased metabolic 
      risk severity (R = 0.27, P = 0.01). In addition, operating time was linked to 
      HbA(1c) (R = 0.30, P = 0.01) and omental MCP-1 protein (R = 0.31, P < 0.01). 
      CONCLUSIONS: MCP-1 is associated with longer operating time and increased 
      metabolic risk severity in older bariatric patients independent of glycaemic 
      control. Pre-operative treatment of inflammation may be required to enhance 
      surgery effectiveness.
FAU - Malin, S K
AU  - Malin SK
AD  - Department of Kinesiology University of Virginia Charlottesville USA.
AD  - Divison of Endocrinology and Metabolism University of Virginia Charlottesville 
      USA.
AD  - Robert M. Berne Cardiovascular Research Center University of Virginia 
      Charlottesville USA.
FAU - Kaplan, J L
AU  - Kaplan JL
AD  - Robert M. Berne Cardiovascular Research Center University of Virginia 
      Charlottesville USA.
AD  - Department of Biochemistry, Molecular Biology, and Genetics University of 
      Virginia Charlottesville USA.
FAU - Meng, L
AU  - Meng L
AD  - Robert M. Berne Cardiovascular Research Center University of Virginia 
      Charlottesville USA.
FAU - Garmey, J C
AU  - Garmey JC
AD  - Robert M. Berne Cardiovascular Research Center University of Virginia 
      Charlottesville USA.
FAU - Kirby, J L
AU  - Kirby JL
AD  - Divison of Endocrinology and Metabolism University of Virginia Charlottesville 
      USA.
FAU - Taylor, A M
AU  - Taylor AM
AD  - Robert M. Berne Cardiovascular Research Center University of Virginia 
      Charlottesville USA.
FAU - Hallowell, P T
AU  - Hallowell PT
AD  - Department of Surgery University of Virginia Charlottesville USA.
FAU - McNamara, C A
AU  - McNamara CA
AD  - Robert M. Berne Cardiovascular Research Center University of Virginia 
      Charlottesville USA.
AD  - Division of Cardiovascular Medicine University of Virginia Charlottesville USA.
AD  - Beirne B. Carter Center for Immunology Research University of Virginia 
      Charlottesville USA.
AD  - Department of Molecular Physiology and Biological Physics University of Virginia 
      Charlottesville USA.
LA  - eng
GR  - T32 AI007496/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20170426
PL  - United States
TA  - Obes Sci Pract
JT  - Obesity science & practice
JID - 101675151
PMC - PMC5478804
OTO - NOTNLM
OT  - Glycaemic control
OT  - inflammation
OT  - insulin resistance
OT  - metabolic syndrome
EDAT- 2017/07/15 06:00
MHDA- 2017/07/15 06:01
PMCR- 2017/04/26
CRDT- 2017/07/15 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2017/03/03 00:00 [revised]
PHST- 2017/03/12 00:00 [accepted]
PHST- 2017/07/15 06:00 [entrez]
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2017/07/15 06:01 [medline]
PHST- 2017/04/26 00:00 [pmc-release]
AID - OSP4105 [pii]
AID - 10.1002/osp4.105 [doi]
PST - epublish
SO  - Obes Sci Pract. 2017 Apr 26;3(2):193-200. doi: 10.1002/osp4.105. eCollection 2017 
      Jun.