PMID- 28707283 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240327 IS - 2509-2723 (Electronic) IS - 2509-2715 (Print) IS - 2509-2723 (Linking) VI - 39 IP - 4 DP - 2017 Aug TI - Multimodal physical activity increases brain-derived neurotrophic factor levels and improves cognition in institutionalized older women. PG - 407-417 LID - 10.1007/s11357-017-9987-5 [doi] AB - Physical activity has been proposed as a promising intervention to improve cognition and decrease the risk of dementia in older adults. Brain-derived neurotrophic factor (BDNF) appears to mediate, at least partially, these effects of exercise. However, intervention studies of the effects of multimodal exercises on cognition and BDNF levels are scarce and composed by small samples. Thus, the generalization of the conclusions of these studies depends on the reproducibility of the results. In order to contribute to the knowledge on the field, the present study evaluated the effects of a physical activity intervention composed by muscle strengthening and aerobic conditioning on BDNF levels and cognition in older women. Independent and non-demented subjects (>/=75 years) were assigned to a 3-month physical activity intervention (n = 22, 60 min exercise sessions three times a week) or to a control condition (n = 10, no exercise). Clinical (anxiety and depression symptoms), neuropsychological (Digit Span, Stroop, Trail Making, and Contextual Memory tests), physical (upper and lower limb strength, aerobic conditioning), and physiological (serum BDNF) parameters were evaluated immediately before, 1 month, and 3 months after starting intervention. Results indicated that controls had stable levels for all measured variables, whereas the intervention group improved on physical fitness, depressive symptoms, cognitive performance, and BDNF levels. Moreover, a linear regression identified an association between aerobic conditioning and BDNF levels. In conclusion, combined muscle strengthening and aerobic conditioning was able to improve cognitive performance and increase BDNF levels. Aerobic conditioning seems to be an important mediator of these outcomes. FAU - Vedovelli, Kelem AU - Vedovelli K AD - Laboratory of Biology and Development of the Nervous System, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, Building 12D, room 34, Porto Alegre, RS, 90619-900, Brazil. AD - Graduate Program in Biomedical Gerontology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6690, Third Floor, Porto Alegre, RS, 90610-000, Brazil. AD - National Institute for Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil. FAU - Giacobbo, Bruno Lima AU - Giacobbo BL AD - Laboratory of Biology and Development of the Nervous System, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, Building 12D, room 34, Porto Alegre, RS, 90619-900, Brazil. AD - National Institute for Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil. AD - Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, building 12A, Second Floor, Porto Alegre, RS, 90619-900, Brazil. FAU - Correa, Marcio Silveira AU - Correa MS AD - Laboratory of Biology and Development of the Nervous System, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, Building 12D, room 34, Porto Alegre, RS, 90619-900, Brazil. AD - National Institute for Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil. AD - Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, building 12A, Second Floor, Porto Alegre, RS, 90619-900, Brazil. FAU - Wieck, Andrea AU - Wieck A AD - Graduate Program in Biomedical Gerontology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6690, Third Floor, Porto Alegre, RS, 90610-000, Brazil. AD - Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Argimon, Irani Iracema de Lima AU - Argimon IIL AD - Graduate Program in Biomedical Gerontology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6690, Third Floor, Porto Alegre, RS, 90610-000, Brazil. FAU - Bromberg, Elke AU - Bromberg E AUID- ORCID: 0000-0002-2900-3673 AD - Laboratory of Biology and Development of the Nervous System, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, Building 12D, room 34, Porto Alegre, RS, 90619-900, Brazil. bromberg@pucrs.br. AD - Graduate Program in Biomedical Gerontology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6690, Third Floor, Porto Alegre, RS, 90610-000, Brazil. bromberg@pucrs.br. AD - National Institute for Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil. bromberg@pucrs.br. AD - Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av., 6681, building 12A, Second Floor, Porto Alegre, RS, 90619-900, Brazil. bromberg@pucrs.br. LA - eng PT - Journal Article DEP - 20170713 PL - Switzerland TA - Geroscience JT - GeroScience JID - 101686284 PMC - PMC5636777 OTO - NOTNLM OT - BDNF OT - Cognitive performance OT - Depression symptom OT - Physical activity COIS- The study was conducted in accordance with the ethical standards of the 1964 Declaration of Helsinki and approved by the Research and Ethics Committee of Pontifical Catholic University, Porto Alegre, Brazil. All participants gave their written informed consent. EDAT- 2017/07/15 06:00 MHDA- 2017/07/15 06:01 PMCR- 2017/07/13 CRDT- 2017/07/15 06:00 PHST- 2017/04/27 00:00 [received] PHST- 2017/06/26 00:00 [accepted] PHST- 2017/07/15 06:00 [pubmed] PHST- 2017/07/15 06:01 [medline] PHST- 2017/07/15 06:00 [entrez] PHST- 2017/07/13 00:00 [pmc-release] AID - 10.1007/s11357-017-9987-5 [pii] AID - 9987 [pii] AID - 10.1007/s11357-017-9987-5 [doi] PST - ppublish SO - Geroscience. 2017 Aug;39(4):407-417. doi: 10.1007/s11357-017-9987-5. Epub 2017 Jul 13.