PMID- 28707660
OWN - NLM
STAT- MEDLINE
DCOM- 20171101
LR  - 20171101
IS  - 0026-8984 (Print)
IS  - 0026-8984 (Linking)
VI  - 51
IP  - 3
DP  - 2017 May-Jun
TI  - [Increase in the concentration of sEH protein in renal medulla of ISIAH rats with 
      inherited stress-induced arterial hypertension].
PG  - 442-446
LID - 10.7868/S0026898417020021 [doi]
AB  - The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal 
      medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. 
      The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of 
      activating endothelial NO-synthase and nitrogen oxide formation, and therefore 
      being vasodilators. An increase in the sEH protein concentration (that we found) 
      allows one to assume that the oxidative stress is increased in the renal medulla 
      of hypertensive rats, and the bloodflow is decreased.
FAU - Abramova, T O
AU  - Abramova TO
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Ryazanova, M A
AU  - Ryazanova MA
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Antonov, E V
AU  - Antonov EV
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Redina, O E
AU  - Redina OE
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
AD  - oredina@ngs.ru.
FAU - Markel, A L
AU  - Markel AL
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
AD  - Novosibirsk State University, Novosibirsk, 630090 Russia.
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Mol Biol (Mosk)
JT  - Molekuliarnaia biologiia
JID - 0105454
RN  - 0 (Nitrogen Oxides)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Disease Models, Animal
MH  - Epoxide Hydrolases/*biosynthesis/isolation & purification
MH  - Humans
MH  - Hypertension/enzymology/pathology
MH  - Kidney Medulla/enzymology/pathology
MH  - Male
MH  - Nitric Oxide Synthase/genetics
MH  - Nitrogen Oxides/metabolism
MH  - Oxidative Stress/*genetics
MH  - Rats
MH  - Stress, Physiological/*genetics
OTO - NOTNLM
OT  - ELISA
OT  - ISIAH rat strain
OT  - arterial hypertension
OT  - real time PCR
OT  - renal medulla
OT  - soluble epoxide hydrolase
EDAT- 2017/07/15 06:00
MHDA- 2017/11/02 06:00
CRDT- 2017/07/15 06:00
PHST- 2016/04/19 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2017/07/15 06:00 [entrez]
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2017/11/02 06:00 [medline]
AID - 10.7868/S0026898417020021 [doi]
PST - ppublish
SO  - Mol Biol (Mosk). 2017 May-Jun;51(3):442-446. doi: 10.7868/S0026898417020021.