PMID- 28708206
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20180831
IS  - 1724-6008 (Electronic)
IS  - 0393-6155 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Jan
TI  - IQGAP1 silencing suppresses the malignant characteristics of laryngeal squamous 
      cell carcinoma cells.
PG  - 73-78
LID - 10.5301/ijbm.5000287 [doi]
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis due to 
      recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a 
      scaffold protein, plays an important role in tumorigenesis and malignant 
      development. In this study, we aimed to explore the role of IQGAP1 in LSCC. 
      METHODS: Expression of IQGAP1 in human LSCC specimens was assessed by 
      immunohistochemistry. We also evaluated the roles of IQGAP1 in cell 
      proliferation, migration and invasion and epithelial-to-mesenchymal transition 
      (EMT) in Hep-2 cells. RESULTS: The expression of IQGAP1 protein was significantly 
      up-regulated in LSCC tissues compared with normal laryngeal tissues (p = 0.002). 
      Furthermore, the knockdown of IQGAP1 in Hep-2 cells inhibited cell growth, 
      migration and invasion. Moreover, we found that IQGAP1 silencing reversed EMT. 
      CONCLUSIONS: These results show for the first time that IQGAP1 is up-regulated in 
      LSCC tissues and plays an important role in LSCC cell proliferation and 
      invasiveness, which indicates that IQGAP1 could work as an oncogene and may serve 
      as a promising molecular target for treatment of LSCC.
FAU - Wang, Xiaoxia
AU  - Wang X
AD  - 1 Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi 
      Medical University, Taiyuan - PR China.
AD  - 3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan - PR China.
FAU - He, Chun
AU  - He C
AD  - 3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan - PR China.
FAU - Li, Chaohui
AU  - Li C
AD  - 3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan - PR China.
FAU - Ren, Benhong
AU  - Ren B
AD  - 3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan - PR China.
FAU - Deng, Qing
AU  - Deng Q
AD  - 3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan - PR China.
FAU - Gao, Wei
AU  - Gao W
AD  - 1 Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi 
      Medical University, Taiyuan - PR China.
AD  - 2 Department of Otolaryngology, Head and Neck tumor key Laboratory of Shanxi 
      Province, Shanxi Medical University, Taiyuan - PR China.
FAU - Wang, Binquan
AU  - Wang B
AD  - 1 Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi 
      Medical University, Taiyuan - PR China.
AD  - 2 Department of Otolaryngology, Head and Neck tumor key Laboratory of Shanxi 
      Province, Shanxi Medical University, Taiyuan - PR China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (IQ motif containing GTPase activating protein 1)
RN  - 0 (ras GTPase-Activating Proteins)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Hep G2 Cells
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Signal Transduction/genetics
MH  - ras GTPase-Activating Proteins/antagonists & inhibitors/*genetics
OTO - NOTNLM
OT  - Epithelial-to-mesenchymal transition
OT  - IQGAP1
OT  - Invasion
OT  - Laryngeal squamous cell carcinoma (LSCC)
EDAT- 2017/07/15 06:00
MHDA- 2018/09/01 06:00
CRDT- 2017/07/15 06:00
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2017/07/15 06:00 [entrez]
AID - 749813D1-5C47-4DD0-AA4A-5D3344B3EA63 [pii]
AID - 10.5301/ijbm.5000287 [doi]
PST - ppublish
SO  - Int J Biol Markers. 2018 Jan;33(1):73-78. doi: 10.5301/ijbm.5000287.