PMID- 28709971
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20180123
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 107
IP  - Pt A
DP  - 2017 Sep
TI  - Epigenetic mechanisms underlying the toxic effects associated with arsenic 
      exposure and the development of diabetes.
PG  - 406-417
LID - S0278-6915(17)30393-9 [pii]
LID - 10.1016/j.fct.2017.07.021 [doi]
AB  - BACKGROUND: Exposure to inorganic arsenic (iAs) is a major threat to the human 
      health worldwide. The consumption of arsenic in drinking water and other food 
      products is associated with the risk of development of type-2 diabetes mellitus 
      (T2DM). The available experimental evidence indicates that epigenetic alterations 
      may play an important role in the development of diseases that are linked with 
      exposure to environmental toxicants. iAs seems to be associated with the 
      epigenetic modifications such as alterations in DNA methylation, histone 
      modifications, and micro RNA (miRNA) abundance. OBJECTIVE: This article reviewed 
      epigenetic mechanisms underlying the toxic effects associated with arsenic 
      exposure and the development of diabetes. METHOD: Electronic databases such as 
      PubMed, Scopus and Google scholar were searched for published literature from 
      1980 to 2017. Searched MESH terms were "Arsenic", "Epigenetic mechanism", "DNA 
      methylation", "Histone modifications" and "Diabetes". RESULTS: There are various 
      factors involved in the pathogenesis of T2DM but it is assumed that arsenic 
      consumption causes the epigenetic alterations both at the gene-specific level and 
      generalized genome level. CONCLUSION: The research indicates that exposure from 
      low to moderate concentrations of iAs is linked with the epigenetic effects. In 
      addition, it is evident that, arsenic can change the components of the epigenome 
      and hence induces diabetes through epigenetic mechanisms, such as alterations in 
      glucose transport and/or metabolism and insulin expression/secretion.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Khan, Fazlullah
AU  - Khan F
AD  - International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, 
      Iran; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, 
      Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and 
      Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Momtaz, Saeideh
AU  - Momtaz S
AD  - Department of Pharmacology and Applied Medicine, Medicinal Plants Research 
      Center, Institute of Medicinal Plants, ACECR, Karaj, Iran; Department of 
      Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Niaz, Kamal
AU  - Niaz K
AD  - International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, 
      Iran; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, 
      Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and 
      Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Hassan, Fatima Ismail
AU  - Hassan FI
AD  - International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, 
      Iran; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, 
      Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and 
      Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
AD  - International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, 
      Iran; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, 
      Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and 
      Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 
      Iran. Electronic address: Mohammad.Abdollahi@UToronto.Ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170711
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Drinking Water)
RN  - 0 (Insulin)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Arsenic/*toxicity
MH  - DNA Methylation
MH  - Diabetes Mellitus, Type 2/*etiology/genetics/metabolism
MH  - Drinking Water/analysis
MH  - Environmental Exposure/*adverse effects
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Insulin/metabolism
OTO - NOTNLM
OT  - Arsenic
OT  - DNA methylation
OT  - Diabetes
OT  - Epigenetic mechanisms
OT  - Histone modifications
OT  - miRNA
EDAT- 2017/07/16 06:00
MHDA- 2018/01/24 06:00
CRDT- 2017/07/16 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/07/07 00:00 [revised]
PHST- 2017/07/08 00:00 [accepted]
PHST- 2017/07/16 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
PHST- 2017/07/16 06:00 [entrez]
AID - S0278-6915(17)30393-9 [pii]
AID - 10.1016/j.fct.2017.07.021 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2017 Sep;107(Pt A):406-417. doi: 10.1016/j.fct.2017.07.021. 
      Epub 2017 Jul 11.