PMID- 28709981
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20170906
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 279
DP  - 2017 Sep 5
TI  - Relative toxicity for indoor semi volatile organic compounds based on neuronal 
      death.
PG  - 33-42
LID - S0378-4274(17)31112-8 [pii]
LID - 10.1016/j.toxlet.2017.07.875 [doi]
AB  - BACKGROUND: Semi Volatile Organic Compounds (SVOCs) are contaminants commonly 
      found in dwellings as a result of their use as plasticizers, flame retardants, or 
      pesticides in building materials and consumer products. Many SVOCs are suspected 
      of being neurotoxic, based on mammal experimentation (impairment of locomotor 
      activity, spatial learning/memory or behavioral changes), raising the question of 
      cumulative risk assessment. The aim of this work is to estimate the relative 
      toxicity of such SVOCs, based on neuronal death. METHOD: SVOCs fulfilling the 
      following conditions were included: detection frequency >10% in dwellings, 
      availability of data on effects or mechanism of action for neurotoxicity, and 
      availability of dose-response relationships based on cell viability assays as a 
      proxy of neuronal death. Benchmark concentration values (BMC) were estimated 
      using a Hill model, and compared to assess relative toxicity. RESULTS: Of the 58 
      SVOCs selected, 28 were suspected of being neurotoxic in mammals, and 21 have 
      been documented as inducing a decrease in cell viability in vitro. 13 have at 
      least one dose-response relationship that can be used to derive a BMC based on a 
      10% fall in neuronal viability. Based on this in vitro endpoint, PCB-153 appeared 
      to be the most toxic compound, having the lowest BMC(10) (0.072muM) and diazinon 
      the least toxic compound, having the highest BMC(10) (94.35muM). We showed that 
      experimental designs (in particular choice of cell lines) had a significant 
      influence on BMC calculation. CONCLUSION: For the first time, the relative in 
      vitro toxicity of 13 indoor contaminants belonging to different chemical families 
      has been assessed on the basis of neuronal cell viability. Lack of comparable 
      toxicity datasets limits the number of SVOCs that can be included. More 
      standardized protocols in terms of cell lines, species and exposure duration 
      should be developed with a view to cumulative risk assessment.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Fournier, Kevin
AU  - Fournier K
AD  - EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon 
      Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in 
      Environmental and Occupational Health), Rennes, France. Electronic address: 
      kevin.fournier01@gmail.com.
FAU - Baumont, Emmanuel
AU  - Baumont E
AD  - EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon 
      Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in 
      Environmental and Occupational Health), Rennes, France. Electronic address: 
      emmanuel.baumont@cstb.fr.
FAU - Glorennec, Philippe
AU  - Glorennec P
AD  - EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon 
      Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in 
      Environmental and Occupational Health), Rennes, France. Electronic address: 
      philippe.glorennec@ehesp.fr.
FAU - Bonvallot, Nathalie
AU  - Bonvallot N
AD  - EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon 
      Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in 
      Environmental and Occupational Health), Rennes, France. Electronic address: 
      nathalie.bonvallot@ehesp.fr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170712
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Air Pollutants)
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - *Air Pollution, Indoor
MH  - Benchmarking
MH  - Cell Death/drug effects
MH  - Cell Line
MH  - Dose-Response Relationship, Drug
MH  - Environmental Monitoring/*methods/standards
MH  - Humans
MH  - Inhalation Exposure/*adverse effects
MH  - Models, Statistical
MH  - Neurons/*drug effects/pathology
MH  - Neurotoxicity Syndromes/*etiology/pathology
MH  - Risk Assessment
MH  - Time Factors
MH  - Toxicity Tests/*methods/standards
MH  - Volatile Organic Compounds/*toxicity
OTO - NOTNLM
OT  - Benchmark concentrations
OT  - Mixture
OT  - Relative toxicity
OT  - Semi volatile organic compounds
EDAT- 2017/07/16 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/07/16 06:00
PHST- 2016/11/14 00:00 [received]
PHST- 2017/07/03 00:00 [revised]
PHST- 2017/07/09 00:00 [accepted]
PHST- 2017/07/16 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/07/16 06:00 [entrez]
AID - S0378-4274(17)31112-8 [pii]
AID - 10.1016/j.toxlet.2017.07.875 [doi]
PST - ppublish
SO  - Toxicol Lett. 2017 Sep 5;279:33-42. doi: 10.1016/j.toxlet.2017.07.875. Epub 2017 
      Jul 12.