PMID- 28710361
OWN - NLM
STAT- MEDLINE
DCOM- 20190116
LR  - 20240326
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jul 14
TI  - The dental phenotype of hairless dogs with FOXI3 haploinsufficiency.
PG  - 5459
LID - 10.1038/s41598-017-05764-5 [doi]
LID - 5459
AB  - Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack 
      of hair and abnormal tooth morphology. This has been attributed to a 
      semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 
      gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant 
      in a historical museum sample of pedigreed hairless dog skulls by using ancient 
      DNA extraction and present the associated dental phenotype. Unlike in the coated 
      wild type dogs, the hairless dogs were characterised in both the mandibular and 
      maxillary dentition by a loss of the permanent canines, premolars and to some 
      extent incisors. In addition, the deciduous fourth premolars and permanent first 
      and second molars consistently lacked the distal and lingual cusps; this resulted 
      in only a single enlarged cusp in the basin-like heel (talonid in lower molars, 
      talon in upper molars). This molar phenotype is also found among several living 
      and fossil carnivorans and the extinct order Creodonta in which it is associated 
      with hypercarnivory. We therefore suggest that FOXI3 may generally be involved in 
      dental (cusp) development within and across mammalian lineages including the 
      hominids which are known to exhibit marked variability in the presence of lingual 
      cusps.
FAU - Kupczik, Kornelius
AU  - Kupczik K
AUID- ORCID: 0000-0003-1502-581X
AD  - Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max 
      Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, 
      Leipzig, Germany. kornelius_kupczik@eva.mpg.de.
AD  - Institut fur Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, 
      Friedrich-Schiller-Universitat, Erbertstrasse 1, 07743, Jena, Germany. 
      kornelius_kupczik@eva.mpg.de.
FAU - Cagan, Alexander
AU  - Cagan A
AD  - Department of Evolutionary Genetics, Max Planck Institute for Evolutionary 
      Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.
AD  - Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
FAU - Brauer, Silke
AU  - Brauer S
AD  - Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max 
      Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, 
      Leipzig, Germany.
FAU - Fischer, Martin S
AU  - Fischer MS
AD  - Institut fur Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, 
      Friedrich-Schiller-Universitat, Erbertstrasse 1, 07743, Jena, Germany.
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170714
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Animals
MH  - Bicuspid/*anatomy & histology/diagnostic imaging
MH  - Cuspid/*anatomy & histology/diagnostic imaging
MH  - Dentition, Permanent
MH  - Dogs
MH  - *Exons
MH  - Female
MH  - Forkhead Transcription Factors/*genetics
MH  - Fossils
MH  - Gene Expression
MH  - Hair/abnormalities
MH  - Incisor/*anatomy & histology/diagnostic imaging
MH  - Male
MH  - Mandible/anatomy & histology/diagnostic imaging
MH  - Maxilla/anatomy & histology/diagnostic imaging
MH  - Molar/*anatomy & histology/diagnostic imaging
MH  - Mutagenesis, Insertional
MH  - Phenotype
MH  - Tomography, X-Ray Computed
MH  - Tooth, Deciduous/anatomy & histology/diagnostic imaging
PMC - PMC5511229
COIS- The authors declare that they have no competing interests.
EDAT- 2017/07/16 06:00
MHDA- 2019/01/17 06:00
PMCR- 2017/07/14
CRDT- 2017/07/16 06:00
PHST- 2016/11/28 00:00 [received]
PHST- 2017/06/02 00:00 [accepted]
PHST- 2017/07/16 06:00 [entrez]
PHST- 2017/07/16 06:00 [pubmed]
PHST- 2019/01/17 06:00 [medline]
PHST- 2017/07/14 00:00 [pmc-release]
AID - 10.1038/s41598-017-05764-5 [pii]
AID - 5764 [pii]
AID - 10.1038/s41598-017-05764-5 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jul 14;7(1):5459. doi: 10.1038/s41598-017-05764-5.