PMID- 28710434
OWN - NLM
STAT- MEDLINE
DCOM- 20190220
LR  - 20190320
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jul 14
TI  - Modifying Dendritic Cell Activation with Plasmonic Nano Vectors.
PG  - 5513
LID - 10.1038/s41598-017-04459-1 [doi]
LID - 5513
AB  - Dendritic cells (DCs) can acquire, process, and present antigens to T-cells to 
      induce an immune response. For this reason, targeting cancer antigens to DCs in 
      order to cause an immune response against cancer is an emerging area of 
      nanomedicine that has the potential to redefine the way certain cancers are 
      treated. The use of plasmonically active silver-coated gold nanorods (henceforth 
      referred to as plasmonic nano vectors (PNVs)) as potential carriers for DC tumor 
      vaccines has not been presented before. Effective carriers must be able to be 
      phagocytized by DCs, present low toxicity, and induce the maturation of DCs-an 
      early indication of an immune response. When we treated DCs with the PNVs, we 
      found that the cell viability of DCs was unaffected, up to 200 mug/ml. 
      Additionally, the PNVs associated with the DCs as they were phagocytized and they 
      were found to reside within intracellular compartments such as endosomes. More 
      importantly, the PNVs were able to induce expression of surface markers 
      indicative of DC activation and maturation, i.e. CD40, CD86, and MHC class II. 
      These results provide the first evidence that PNVs are promising carriers for 
      DC-based vaccines and warrant further investigating for clinical use.
FAU - Vang, Kieng Bao
AU  - Vang KB
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA. 
      kbvangdings@ualr.edu.
FAU - Safina, Ingrid
AU  - Safina I
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Darrigues, Emilie
AU  - Darrigues E
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Nedosekin, Dmitry
AU  - Nedosekin D
AD  - Arkansas Nanomedicine Center, Winthrop P. Rockefeller Cancer Institute, 
      University of Arkansas for Medical Sciences, 4301 West Markham Street, Little 
      Rock, AR, 72205, USA.
FAU - Nima, Zeid A
AU  - Nima ZA
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Majeed, Waqar
AU  - Majeed W
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Watanabe, Fumiya
AU  - Watanabe F
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Kannarpady, Ganesh
AU  - Kannarpady G
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Kore, Rajshekhar A
AU  - Kore RA
AD  - Department of Radiation Oncology, Winthrop P. Rockefeller Cancer Institute, 
      University of Arkansas for Medical Sciences, 4301 West Markham Street, Little 
      Rock, AR, 72205, USA.
FAU - Casciano, Daniel
AU  - Casciano D
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
FAU - Zharov, Vladimir P
AU  - Zharov VP
AD  - Arkansas Nanomedicine Center, Winthrop P. Rockefeller Cancer Institute, 
      University of Arkansas for Medical Sciences, 4301 West Markham Street, Little 
      Rock, AR, 72205, USA.
FAU - Griffin, Robert J
AU  - Griffin RJ
AD  - Department of Radiation Oncology, Winthrop P. Rockefeller Cancer Institute, 
      University of Arkansas for Medical Sciences, 4301 West Markham Street, Little 
      Rock, AR, 72205, USA.
FAU - Dings, Ruud P M
AU  - Dings RPM
AD  - Department of Radiation Oncology, Winthrop P. Rockefeller Cancer Institute, 
      University of Arkansas for Medical Sciences, 4301 West Markham Street, Little 
      Rock, AR, 72205, USA.
FAU - Biris, Alexandru S
AU  - Biris AS
AD  - Center for Integrative Nanotechnology Sciences, University of Arkansas at Little 
      Rock, 2801 S University Avenue, Little Rock, AR, 72204, USA.
LA  - eng
GR  - P20 GM103625/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170714
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (B7-2 Antigen)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cd86 protein, mouse)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 3M4G523W1G (Silver)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - B7-2 Antigen/*metabolism
MH  - CD40 Antigens/*metabolism
MH  - Cell Differentiation/drug effects
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Dendritic Cells/cytology/drug effects/*immunology
MH  - Gold/*pharmacology
MH  - Histocompatibility Antigens Class II/*pharmacology
MH  - Metal Nanoparticles/chemistry
MH  - Mice
MH  - Nanotubes/chemistry
MH  - Phagocytosis
MH  - Silver/*pharmacology
PMC - PMC5511287
COIS- The authors declare that they have no competing interests.
EDAT- 2017/07/16 06:00
MHDA- 2019/03/21 06:00
PMCR- 2017/07/14
CRDT- 2017/07/16 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/07/16 06:00 [entrez]
PHST- 2017/07/16 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2017/07/14 00:00 [pmc-release]
AID - 10.1038/s41598-017-04459-1 [pii]
AID - 4459 [pii]
AID - 10.1038/s41598-017-04459-1 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jul 14;7(1):5513. doi: 10.1038/s41598-017-04459-1.