PMID- 28710956
OWN - NLM
STAT- MEDLINE
DCOM- 20180424
LR  - 20180424
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 84
DP  - 2017 Oct
TI  - Oxytocin receptor antagonist treatments alter levels of attachment to mothers and 
      central dopamine activity in pre-weaning mandarin vole pups.
PG  - 124-134
LID - S0306-4530(17)30111-7 [pii]
LID - 10.1016/j.psyneuen.2017.06.020 [doi]
AB  - Oxytocin (OT) is known to be important in mother-infant bonding. Although the 
      relationship between OT and filial attachment behavior has been studied in a few 
      mammalian species, the effects on infant social behavior have received little 
      attention in monogamous species. The present study examined the effects of OT 
      receptor antagonist (OTA) treatment on attachment behavior and central dopamine 
      (DA) activity in male and female pre-weaning mandarin voles (Microtus 
      mandarinus). Our data showed that OTA treatments decreased the attachment 
      behavior of pups to mothers, measured using preference tests at postnatal day 14, 
      16, 18 and 20. OTA treatments reduced serum OT concentration in pre-weaning pups 
      and decreased tyrosine hydroxylase (TH) levels in the ventral tegmental area 
      (VTA), indicating a decrease in central DA activity. In male and female pups, OTA 
      reduced DA levels, DA 1-type receptor (D1R) and DA 2-type receptor (D2R) protein 
      expression in the nucleus accumbens (NAcc). Our results indicate that OTA 
      treatment inhibits the attachment of pre-weaning pups to mothers. This inhibition 
      is possibly associated with central DA activity and levels of two types of 
      dopamine receptor in the NAcc.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - He, Zhixiong
AU  - He Z
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Hou, Wenjuan
AU  - Hou W
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Hao, Xin
AU  - Hao X
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Dong, Na
AU  - Dong N
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Du, Peirong
AU  - Du P
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Yuan, Wei
AU  - Yuan W
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Yang, Jinfeng
AU  - Yang J
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China.
FAU - Jia, Rui
AU  - Jia R
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China; Cognition Neuroscience and Learning 
      Division, Key Laboratory of Modern Teaching Technology, Ministry of Education, 
      Shaanxi Normal University, Xi'an, 710062, China.
FAU - Tai, Fadao
AU  - Tai F
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, China; Cognition Neuroscience and Learning 
      Division, Key Laboratory of Modern Teaching Technology, Ministry of Education, 
      Shaanxi Normal University, Xi'an, 710062, China. Electronic address: 
      taifadao@snnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170706
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Oxytocin)
RN  - 50-56-6 (Oxytocin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Arvicolinae/metabolism/physiology
MH  - Dopamine/metabolism/pharmacology
MH  - Female
MH  - Male
MH  - Maternal Behavior
MH  - Mothers
MH  - Nucleus Accumbens/metabolism
MH  - *Object Attachment
MH  - Oxytocin/metabolism/*pharmacology
MH  - Receptors, Dopamine/metabolism
MH  - Receptors, Oxytocin/*antagonists & inhibitors
MH  - Social Behavior
MH  - Ventral Tegmental Area/metabolism
MH  - Weaning
OTO - NOTNLM
OT  - Attachment
OT  - Dopamine
OT  - Mandarin vole pups
OT  - Nucleus accumbens
OT  - Oxytocin receptor antagonist
EDAT- 2017/07/16 06:00
MHDA- 2018/04/25 06:00
CRDT- 2017/07/16 06:00
PHST- 2017/02/01 00:00 [received]
PHST- 2017/06/25 00:00 [revised]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/07/16 06:00 [pubmed]
PHST- 2018/04/25 06:00 [medline]
PHST- 2017/07/16 06:00 [entrez]
AID - S0306-4530(17)30111-7 [pii]
AID - 10.1016/j.psyneuen.2017.06.020 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2017 Oct;84:124-134. doi: 
      10.1016/j.psyneuen.2017.06.020. Epub 2017 Jul 6.