PMID- 28710978
OWN - NLM
STAT- MEDLINE
DCOM- 20171221
LR  - 20181202
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 230
DP  - 2017 Nov
TI  - Relationships between POPs, biometrics and circulating steroids in male polar 
      bears (Ursus maritimus) from Svalbard.
PG  - 598-608
LID - S0269-7491(17)30611-5 [pii]
LID - 10.1016/j.envpol.2017.06.095 [doi]
AB  - The aim of this study was to determine the effects of persistent organic 
      pollutants (POPs) and biometric variables on circulating levels of steroid 
      hormones (androgens, estrogens and progestagens) in male polar bears (Ursus 
      maritimus) from Svalbard, Norway (n = 23). Levels of pregnenolone (PRE), 
      progesterone (PRO), androstenedione (AN), dehydroepiandrosterone (DHEA), 
      testosterone (TS), dihydrotestosterone (DHT), estrone (E1), 17alpha-estradiol (alphaE2) 
      and 17beta-estradiol (betaE2) were quantified in polar bear serum by gas chromatography 
      tandem mass spectrometry (GC-MS/MS), while POPs were measured in plasma. 
      Subsequently, associations between hormone concentrations (9 steroids), POPs (21 
      polychlorinated biphenyls (PCBs), 8 OH-PCBs, 8 organochlorine pesticides (OCPs) 
      and OCP metabolites, and 2 polybrominated diphenyl ethers (PBDEs)) and biological 
      variables (age, head length, body mass, girth, body condition index), capture 
      date, location (latitude and longitude), lipid content and cholesterol levels 
      were examined using principal component analysis (PCA) and orthogonal projections 
      to latent structures (OPLS) modelling. Average concentrations of androgens, 
      estrogens and progestagens were in the range of 0.57-83.7 (0.57-12.4 for 
      subadults, 1.02-83.7 for adults), 0.09-2.69 and 0.57-2.44 nmol/L, respectively. 
      The steroid profiles suggest that sex steroids were mainly synthesized through 
      the Delta-4 pathway in male polar bears. The ratio between androgens and estrogens 
      significantly depended on sexual maturity with androgen/estrogen ratios being 
      approximately 60 times higher in adult males than in subadult males. PCA plots 
      and OPLS models indicated that TS was positively related to biometrics, such as 
      body condition index in male polar bears. A negative relationship was also 
      observed between POPs and DHT. Consequently, POPs and body condition may 
      potentially affect the endocrinological function of steroids, including 
      development of reproductive tissues and sex organs and the general condition of 
      male polar bears.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Ciesielski, Tomasz M
AU  - Ciesielski TM
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
FAU - Hansen, Ingunn Tjelta
AU  - Hansen IT
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
FAU - Bytingsvik, Jenny
AU  - Bytingsvik J
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
FAU - Hansen, Martin
AU  - Hansen M
AD  - Toxicology Laboratory, Department of Pharmacy, Faculty of Health and Medical 
      Sciences, University of Copenhagen, Denmark.
FAU - Lie, Elisabeth
AU  - Lie E
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Aars, Jon
AU  - Aars J
AD  - Norwegian Polar Institute, Tromso, Norway.
FAU - Jenssen, Bjorn M
AU  - Jenssen BM
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway; Department of Arctic Technology, The University Centre in Svalbard, 
      Longyearbyen, Norway.
FAU - Styrishave, Bjarne
AU  - Styrishave B
AD  - Toxicology Laboratory, Department of Pharmacy, Faculty of Health and Medical 
      Sciences, University of Copenhagen, Denmark. Electronic address: 
      Bjarne.styrishave@sund.ku.dk.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Aging/*blood
MH  - Animals
MH  - Body Weights and Measures
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Gonadal Steroid Hormones/*blood
MH  - Hydrocarbons, Brominated/*blood
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Svalbard
MH  - Tandem Mass Spectrometry
MH  - Ursidae/*blood/growth & development
OTO - NOTNLM
OT  - Androgens
OT  - Dihydrotestosterone
OT  - Estrogens
OT  - GC-MS/MS
OT  - Progestagens
OT  - Steroid hormones
OT  - Steroidogenesis
OT  - Testosterone
EDAT- 2017/07/16 06:00
MHDA- 2017/12/22 06:00
CRDT- 2017/07/16 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/05/16 00:00 [revised]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/07/16 06:00 [pubmed]
PHST- 2017/12/22 06:00 [medline]
PHST- 2017/07/16 06:00 [entrez]
AID - S0269-7491(17)30611-5 [pii]
AID - 10.1016/j.envpol.2017.06.095 [doi]
PST - ppublish
SO  - Environ Pollut. 2017 Nov;230:598-608. doi: 10.1016/j.envpol.2017.06.095. Epub 
      2017 Jul 12.