PMID- 28711394
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20191210
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 179
DP  - 2017 Oct 1
TI  - Exercise prevents IFN-alpha-induced mood and cognitive dysfunction and increases BDNF 
      expression in the rat.
PG  - 377-383
LID - S0031-9384(17)30218-4 [pii]
LID - 10.1016/j.physbeh.2017.07.018 [doi]
AB  - Aerobic exercise has marked effects on mood and cognition. Here, we used an 
      interferon-alpha (IFN-alpha) induced depression model to evaluate the potential 
      efficacy of chronic treadmill running on mood and cognition in the rat. IFN-alpha 
      treatment induces behavioral deficits in the forced swim test (FST), open field 
      test and object exploration task. Male han Wistar rats (n=8 per group, 3month 
      old) were injected 3 times weekly with recombinant human IFN-alpha or saline 
      (control) for 4weeks. One group was exercised 3 times (1h treadmill running) per 
      week while the other remained sedentary. Animals were tested for anxiety- and 
      depressive-like behavior in the open field test and FST. Spatial and recognition 
      memory were examined by the object exploration task. Hippocampal and prefrontal 
      cortex brain samples were harvested for analysis of brain-derived neurotrophic 
      factor (BDNF). Treadmill running prevented IFN-alpha-induced decreased central arena 
      exploration in the open field test and decreased immobility in the FST. IFN-alpha 
      treated rats had impaired spatial memory in the object exploration task compared 
      to saline controls, which was prevented by treadmill running. Further, treadmill 
      running improved recognition memory in both saline and IFN-alpha treated rats. 
      Treadmill running protected against IFN-alpha induced decreases in expression of BDNF 
      in the hippocampus and prefrontal cortex. Aerobic exercise protects against IFN-alpha 
      induced affective and cognitive dysfunction, which is associated with increased 
      BDNF. Results could have implications for future treatments of depression.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Callaghan, Charlotte K
AU  - Callaghan CK
AD  - Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. 
      Electronic address: callaghc@tcd.ie.
FAU - Rouine, Jennifer
AU  - Rouine J
AD  - Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland.
FAU - O'Mara, Shane M
AU  - O'Mara SM
AD  - Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Anxiety/metabolism/therapy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*physiology
MH  - Depressive Disorder/metabolism/psychology/*therapy
MH  - Disease Models, Animal
MH  - *Exercise Therapy
MH  - Exploratory Behavior/physiology
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Interferon-alpha
MH  - Male
MH  - Prefrontal Cortex/metabolism
MH  - Rats, Wistar
MH  - Recognition, Psychology/physiology
MH  - Recombinant Proteins
MH  - Running/*physiology/*psychology
MH  - Spatial Memory/physiology
OTO - NOTNLM
OT  - BDNF
OT  - Cognition
OT  - Depression
OT  - Exercise
OT  - IFN-alpha
OT  - Memory
EDAT- 2017/07/18 06:00
MHDA- 2018/05/02 06:00
CRDT- 2017/07/17 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/07/11 00:00 [revised]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2017/07/18 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/07/17 06:00 [entrez]
AID - S0031-9384(17)30218-4 [pii]
AID - 10.1016/j.physbeh.2017.07.018 [doi]
PST - ppublish
SO  - Physiol Behav. 2017 Oct 1;179:377-383. doi: 10.1016/j.physbeh.2017.07.018. Epub 
      2017 Jul 12.