PMID- 28712428
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20220321
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 99
DP  - 2017 Aug
TI  - Association between all-cause mortality and severity of depressive symptoms in 
      patients with type 2 diabetes: Analysis from the Japan Diabetes Complications 
      Study (JDCS).
PG  - 34-39
LID - S0022-3999(16)30647-X [pii]
LID - 10.1016/j.jpsychores.2017.05.020 [doi]
AB  - OBJECTIVE: The aims of this study are to confirm whether the excess mortality 
      caused by depressive symptoms is independent of severe hypoglycemia in patients 
      with type 2 diabetes mellitus (T2DM) and to evaluate the association between 
      all-cause mortality and degrees of severity of depressive symptoms in Japanese 
      patients with T2DM. METHODS: A total of 1160 Japanese patients with T2DM were 
      eligible for this analysis. Participants were followed prospectively for 3years 
      and their depressive states were evaluated at baseline by the Center for 
      Epidemiologic Studies Depression Scale (CES-D). Cox proportional hazards model 
      was used to evaluate the relative risk of all-cause mortality and was adjusted by 
      possible confounding factors, including severe hypoglycemia, all of which are 
      known as risk factors for both depression and mortality. RESULTS: After 
      adjustment for severe hypoglycemia, each 5-point increase in the CES-D score was 
      significantly associated with excess all-cause mortality (hazard ratio 1.69 [95% 
      CI 1.26-2.17]). The spline curve of HRs for mortality according to total CES-D 
      scores showed that mortality risk was slightly increased at lower scores but was 
      sharply elevated at higher scores. CONCLUSION: A high score on the CES-D at 
      baseline was significantly associated with all-cause mortality in patients with 
      T2DM after adjusting for confounders including severe hypoglycemia. However, only 
      a small effect on mortality risk was found at relatively lower levels of 
      depressive symptoms in this population. Further research is needed to confirm 
      this relationship between the severity of depressive symptoms and mortality in 
      patients with T2DM.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Matsunaga, Satoshi
AU  - Matsunaga S
AD  - Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, 
      Niigata University, Niigata, Japan.
FAU - Tanaka, Shiro
AU  - Tanaka S
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Fujihara, Kazuya
AU  - Fujihara K
AD  - Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, 
      Niigata University, Niigata, Japan.
FAU - Horikawa, Chika
AU  - Horikawa C
AD  - Department of Health and Nutrition, Faculty of Human Life Studies, University of 
      Niigata Prefecture, Niigata, Japan.
FAU - Iimuro, Satoshi
AU  - Iimuro S
AD  - Teikyo Academic Research Center, Teikyo University, Tokyo, Japan.
FAU - Kitaoka, Masafumi
AU  - Kitaoka M
AD  - Division of Endocrinology and Metabolism, Showa General Hospital, Tokyo, Japan.
FAU - Sato, Asako
AU  - Sato A
AD  - Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Nakamura, Jiro
AU  - Nakamura J
AD  - Division of Diabetes, Department of Internal Medicine, Aichi Medical University 
      School of Medicine, Aichi, Japan.
FAU - Haneda, Masakazu
AU  - Haneda M
AD  - Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa 
      Medical University, Hokkaido, Japan.
FAU - Shimano, Hitoshi
AU  - Shimano H
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
FAU - Akanuma, Yasuo
AU  - Akanuma Y
AD  - The Institute for Adult Diseases Asahi Life Foundation, Tokyo, Japan.
FAU - Ohashi, Yasuo
AU  - Ohashi Y
AD  - Department of Integrated Science and Engineering for Sustainable Society, Chuo 
      University, Tokyo, Japan.
FAU - Sone, Hirohito
AU  - Sone H
AD  - Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, 
      Niigata University, Niigata, Japan. Electronic address: sone@med.niigata-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20170531
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
SB  - IM
MH  - Adult
MH  - Aged
MH  - Depression/*etiology/mortality
MH  - Diabetes Complications/*complications
MH  - Diabetes Mellitus, Type 2/mortality/pathology/*psychology
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Survival Analysis
OTO - NOTNLM
OT  - Death
OT  - Depressive disorder
OT  - Diabetes mellitus, type 2
OT  - Hypoglycemia
EDAT- 2017/07/18 06:00
MHDA- 2018/01/19 06:00
CRDT- 2017/07/18 06:00
PHST- 2016/12/28 00:00 [received]
PHST- 2017/05/19 00:00 [revised]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/07/18 06:00 [entrez]
PHST- 2017/07/18 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
AID - S0022-3999(16)30647-X [pii]
AID - 10.1016/j.jpsychores.2017.05.020 [doi]
PST - ppublish
SO  - J Psychosom Res. 2017 Aug;99:34-39. doi: 10.1016/j.jpsychores.2017.05.020. Epub 
      2017 May 31.