PMID- 28713531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2035-8385 (Print)
IS  - 2035-8377 (Electronic)
IS  - 2035-8385 (Linking)
VI  - 9
IP  - 2
DP  - 2017 Jun 23
TI  - The Effects of Fasting During Ramadan on the Concentration of Serotonin, 
      Dopamine, Brain-Derived Neurotrophic Factor and Nerve Growth Factor.
PG  - 7043
LID - 10.4081/ni.2017.7043 [doi]
LID - 7043
AB  - Neurotransmitters and neurotrophic factors are signaling molecules that play a 
      crucial role in cell proliferation, differentiation, survival and functions of 
      neurons. It is believed that caloric restriction could help the health of the 
      nervous system by affecting the synthesis of neurotrophins and neurotransmitter 
      and oxygen radical metabolism. The objective was to investigate the plasma levels 
      of serotonin, dopamine, brain-derived neurotrophic factor (BDNF), and nerve 
      growth factor (NGF) in 29 healthy fasted subjects (22 women and 7 men) during the 
      month of fasting in Ramadan. The levels of these factors were measured (using 
      ELISA method) three times, 2 days before the fasting month as a control, on the 
      14(th) and 29(th) day of Ramadan as test groups. In addition, these factors were 
      investigated in the group of women only. According to our investigation, the 
      plasma levels of serotonin, BDNF and NGF were significantly increased during 
      fasting month of Ramadan. In detail, the levels of these factors were increased 
      in 14(th) and 29(th) day test groups compared to controls (P<0.05). Moreover, 
      these levels were significantly increased on the 29(th) day compared to the 
      14(th) day test groups, but there were no differences between dopamine levels in 
      all groups. Furthermore, the results obtained in women's groups were the same as 
      those obtained in previous groups. Our findings suggest that plasma levels of 
      serotonin, BDNF and NGF were significantly increased during fasting month of 
      Ramadan.
FAU - Bastani, Abdolhossein
AU  - Bastani A
AD  - Biochemistry Department, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Rajabi, Sadegh
AU  - Rajabi S
AD  - Biochemistry Department, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Kianimarkani, Fatemeh
AU  - Kianimarkani F
AD  - Biochemistry Department, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20170623
PL  - Switzerland
TA  - Neurol Int
JT  - Neurology international
JID - 101551564
PMC - PMC5505095
OTO - NOTNLM
OT  - BDNF
OT  - Caloric restriction
OT  - Dopamine
OT  - NGF
OT  - Serotonin
EDAT- 2017/07/18 06:00
MHDA- 2017/07/18 06:01
PMCR- 2017/06/23
CRDT- 2017/07/18 06:00
PHST- 2017/01/11 00:00 [received]
PHST- 2017/04/24 00:00 [revised]
PHST- 2017/05/17 00:00 [accepted]
PHST- 2017/07/18 06:00 [entrez]
PHST- 2017/07/18 06:00 [pubmed]
PHST- 2017/07/18 06:01 [medline]
PHST- 2017/06/23 00:00 [pmc-release]
AID - 10.4081/ni.2017.7043 [doi]
PST - epublish
SO  - Neurol Int. 2017 Jun 23;9(2):7043. doi: 10.4081/ni.2017.7043. eCollection 2017 
      Jun 23.