PMID- 28713662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 9
IP  - 6
DP  - 2017 Jun 13
TI  - Subacute Sclerosing Panencephalitis in a Child Suffering from Human 
      Immunodeficiency Virus on "Highly Active Antiretroviral Therapy" - Can This be 
      Another Instance of Immune Reconstitution Inflammatory Syndrome?
PG  - e1346
LID - 10.7759/cureus.1346 [doi]
LID - e1346
AB  - We report a 12-year-old boy with human immunodeficiency virus (HIV) who presented 
      with rapidly progressive difficulty in ambulation. The symptoms started to worsen 
      when he was put on antiretroviral therapy (ART). Our findings show that the 
      dynamics of HIV-related immune suppression and highly active antiretroviral 
      therapy (HAART) have an impact on the clinical course of Subacute sclerosing 
      panencephalitis (SSPE). Slow progression is expected in children on HAART but in 
      our case, we observe a complex interaction of the virus with the immune system 
      and modification of disease course of SSPE with ART. The child we discuss in this 
      case report developed rapidly progressive SSPE on HAART regime; so 
      the possibility of SSPE to be labeled as immune reconstitution inflammatory 
      syndrome (IRIS) should be considered.
FAU - Gupta, Ashutosh
AU  - Gupta A
AD  - Senior Resident, Department of Neurology, Institute of Human Behaviour and Allied 
      Sciences (IHBAS), Delhi, India.
FAU - Kushwaha, Suman
AU  - Kushwaha S
AD  - Associate Professor & HOD, Department of Neurology, Institute of Human Behaviour 
      and Allied Sciences (IHBAS), Delhi, India.
FAU - Manzoor, Mushbiq
AU  - Manzoor M
AD  - Resident, Department of Neurology, Institute of Human Behaviour and Allied 
      Sciences (IHBAS), Delhi, India.
FAU - Tarfarosh, Shah Faisal Ahmad
AU  - Tarfarosh SFA
AD  - Resident, Department of Neurology, Institute of Human Behaviour and Allied 
      Sciences (IHBAS), Delhi, India.
LA  - eng
PT  - Case Reports
DEP - 20170613
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC5509242
OTO - NOTNLM
OT  - highly active antiretroviral therapy (haart)
OT  - hiv
OT  - immune reconstitution inflammatory syndrome
OT  - neurology
OT  - sspe
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/07/18 06:00
MHDA- 2017/07/18 06:01
PMCR- 2017/06/13
CRDT- 2017/07/18 06:00
PHST- 2017/07/18 06:00 [entrez]
PHST- 2017/07/18 06:00 [pubmed]
PHST- 2017/07/18 06:01 [medline]
PHST- 2017/06/13 00:00 [pmc-release]
AID - 10.7759/cureus.1346 [doi]
PST - epublish
SO  - Cureus. 2017 Jun 13;9(6):e1346. doi: 10.7759/cureus.1346.