PMID- 28713833
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in 
      Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health 
      Records.
PG  - 2835981
LID - 10.1155/2017/2835981 [doi]
LID - 2835981
AB  - OBJECTIVE: To investigate the relationship between hemoglobin levels and diabetic 
      peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM). METHODS: 1511 
      patients with T2DM were included in the study. DPN was diagnosed based on 
      symptoms, signs, and laboratory tests. Hemoglobin was defined as both a 
      continuous variable and a quartile category variable. We compared patient 
      characteristics between the no diabetic peripheral neuropathy (NDPN) and DPN 
      groups. Logistic regression was conducted to investigate the association of DPN 
      with hemoglobin in all T2DM patients. Linear regression was also performed to 
      investigate the impact of hemoglobin on the vibrating perception threshold (VPT). 
      RESULTS: Compared with the NDPN group, hemoglobin level in the DPN group was 
      significantly lower (118.54 +/- 16.91 versus 131.62 +/- 18.32 g/L, P < 0.01). The 
      prevalence of DPN increased by 50.1% (95% CI: 42.2-57.0%; P < 0.001) per standard 
      deviation decrease in hemoglobin. Compared to the highest quartile of hemoglobin, 
      the lower quartiles were associated with a significantly increased risk of DPN in 
      the entire T2DM population (all P < 0.01). A per unit decrease in hemoglobin 
      leads to a 0.12 (95% CI: 0.07-0.168) unit increase in VPT after adjustment for 
      possible confounders (P < 0.001). CONCLUSIONS: Lower hemoglobin levels were 
      associated with increased prevalence of DPN and higher VPT.
FAU - Yang, Jun
AU  - Yang J
AUID- ORCID: 0000-0002-5487-2248
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan, China.
FAU - Yan, Pi-Jun
AU  - Yan PJ
AUID- ORCID: 0000-0001-6692-2401
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan, China.
FAU - Wan, Qin
AU  - Wan Q
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan, China.
FAU - Li, Hua
AU  - Li H
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan, China.
LA  - eng
PT  - Journal Article
DEP - 20170621
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Diabetic Neuropathies/*blood/epidemiology
MH  - Electronic Health Records
MH  - Female
MH  - Hemoglobins/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC5497611
EDAT- 2017/07/18 06:00
MHDA- 2018/04/24 06:00
PMCR- 2017/06/21
CRDT- 2017/07/18 06:00
PHST- 2017/03/07 00:00 [received]
PHST- 2017/06/06 00:00 [accepted]
PHST- 2017/07/18 06:00 [entrez]
PHST- 2017/07/18 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/06/21 00:00 [pmc-release]
AID - 10.1155/2017/2835981 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:2835981. doi: 10.1155/2017/2835981. Epub 2017 Jun 21.