PMID- 28715068
OWN - NLM
STAT- MEDLINE
DCOM- 20180126
LR  - 20180126
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 75
IP  - 12
DP  - 2017
TI  - Severe mitral regurgitation is associated with increased copeptin levels in heart 
      failure with reduced ejection fraction.
PG  - 1307-1314
LID - 10.5603/KP.a2017.0140 [doi]
AB  - BACKGROUND AND AIM: The objective of this study was to assess the potential role 
      of mitral regurgitation (MR) in the release of copeptin in heart failure patients 
      with reduced ejection fraction (HFrEF). METHODS: The study included 63 patients 
      of whom 33 had functional mild MR (Group 1) and 30 had functional severe MR 
      (Group 2). The functional class of both groups was New York Heart Association 
      (NYHA) Class III. Blood samples for the determination of plasma copeptin and 
      B-type natriuretic peptide (BNP) levels were obtained on the same day with the 
      echo-cardiographic examination. Standard echocardiographic studies were 
      performed. RESULTS: Copeptin and BNP levels showed a substantial agreement in the 
      whole study group (Kappa level: 0.607, p < 0.0001). Also, copeptin and BNP showed 
      a strong correlation and were both increased and significantly higher in Group 2 
      than in Group 1 (p < 0.001 and p < 0.05, respectively). Left ventricular global 
      longitudinal strain and left ventricular ejection fraction values were similar in 
      both groups. The study population were divided into two subgroups on the basis of 
      copeptin median level (6.4 ng/mL), and the prevalence of severe MR was 
      significantly higher in the above-median-copeptin subgroup. A linear regression 
      analysis showed that the presence of severe MR was the only independent predictor 
      of high circulating plasma copeptin level (OR 7.5, 95% CI 2.8-12.1; p = 0.002). 
      CONCLUSIONS: Severe MR is an independent predictor of elevated plasma copeptin 
      level in HFREF irrespective of systolic function.
FAU - Kilicgedik, Alev
AU  - Kilicgedik A
AD  - KARTAL KOSUYOLU RESEARCH AND TRAINING HOSPITAL, TURKEY. akilicgedik@yahoo.com.
FAU - Eroglu, Elif
AU  - Eroglu E
FAU - Kahveci, Gokhan
AU  - Kahveci G
FAU - Isgandarov, Khagani
AU  - Isgandarov K
FAU - Acar, Emrah
AU  - Acar E
FAU - Ozturk, Semi
AU  - Ozturk S
FAU - Zehir, Regayip
AU  - Zehir R
FAU - Kulahcioglu, Seyhmus
AU  - Kulahcioglu S
FAU - Toprak, Cuneyt
AU  - Toprak C
FAU - Yaman, Ali
AU  - Yaman A
FAU - Izgi, Ibrahim Akin
AU  - Izgi IA
FAU - Kirma, Cevat
AU  - Kirma C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170717
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (Biomarkers)
RN  - 0 (Glycopeptides)
RN  - 0 (copeptins)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Biomarkers/blood
MH  - Echocardiography
MH  - Echocardiography, Doppler
MH  - Female
MH  - Glycopeptides/*blood
MH  - Heart Failure/*blood/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnostic imaging/*physiopathology
MH  - Natriuretic Peptide, Brain/blood
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
OTO - NOTNLM
OT  - copeptin
OT  - functional mitral regurgitation
OT  - heart failure
EDAT- 2017/07/18 06:00
MHDA- 2018/01/27 06:00
CRDT- 2017/07/18 06:00
PHST- 2017/02/27 00:00 [received]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/06/02 00:00 [revised]
PHST- 2017/07/18 06:00 [pubmed]
PHST- 2018/01/27 06:00 [medline]
PHST- 2017/07/18 06:00 [entrez]
AID - VM/OJS/KP/11214 [pii]
AID - 10.5603/KP.a2017.0140 [doi]
PST - ppublish
SO  - Kardiol Pol. 2017;75(12):1307-1314. doi: 10.5603/KP.a2017.0140. Epub 2017 Jul 17.