PMID- 28716139
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20220410
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Jul 17
TI  - Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and 
      glycemic load associated with type 2 diabetes mellitus in rural Thais: a 
      cross-sectional study.
PG  - 44
LID - 10.1186/s12902-017-0189-z [doi]
LID - 44
AB  - BACKGROUND: The elevated levels of inflammatory markers, including C-reactive 
      protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL6) are 
      supposed to be associated with type 2 diabetes mellitus (T2DM). Frequent high 
      glycemic load (GL) consumption, central obesity, and a lack of physical activity 
      are considered to be T2DM risk factors. This study aimed to determine the 
      difference of these inflammatory markers as well as GL in individuals with versus 
      those without T2DM in rural Thais. METHODS: A total of 296 participants aged 
      35-66 living in Sung Noen District, Nakhon Ratchasima Province, Thailand, were 
      recruited. Blood was collected to evaluate blood glucose levels, lipid profiles, 
      and inflammatory markers. A Semi-food frequency questionnaire was utilized to 
      assess GL followed by socioeconomic and anthropometric assessment. Statistical 
      analysis was subsequently performed. RESULTS: Elevated CRP and IL6 levels were 
      associated with increased risk of developing T2DM [OR (95% CI): 7.51 (2.11, 
      26.74) and 4.95 (1.28, 19.11)], respectively. There was a trend towards increased 
      risk of T2DM with elevated TNF-alpha levels [OR (95% CI): 1.56 (0.39, 6.14)]. GL 
      correlated significantly with fasting blood glucose (r = 0.289, P = 0.016), 
      suggesting that it is involved in T2DM in this study group. CONCLUSION: In this 
      study, CRP, IL6, and TNF-alpha associated with T2DM. Our findings suggested that 
      these inflammatory markers, especially CRP, may initiate T2DM.
FAU - Phosat, Chanchira
AU  - Phosat C
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
FAU - Panprathip, Pornpimol
AU  - Panprathip P
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
FAU - Chumpathat, Noppanath
AU  - Chumpathat N
AD  - Faculty of Nursing, Huachiew Chalermprakiet University, 18/18 Bangna-Trad Rd, 
      Samut Prakan, 10540, Thailand.
FAU - Prangthip, Pattaneeya
AU  - Prangthip P
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
FAU - Chantratita, Narisara
AU  - Chantratita N
AD  - Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol 
      University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
FAU - Soonthornworasiri, Ngamphol
AU  - Soonthornworasiri N
AD  - Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, 
      420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
FAU - Puduang, Somchai
AU  - Puduang S
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
FAU - Kwanbunjan, Karunee
AU  - Kwanbunjan K
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand. 
      karunee.kwa@mahidol.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20170717
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Biomarkers)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - C-Reactive Protein/*analysis
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycemic Load
MH  - Humans
MH  - Insulin Resistance
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Rural Population
MH  - Thailand/epidemiology
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC5512726
OTO - NOTNLM
OT  - CRP
OT  - Glycemic load
OT  - IL6
OT  - TNF-alpha
OT  - Type 2 diabetes mellitus
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Written informed consent was obtained 
      from all participants. The study was approved by the Ethics Committee of the 
      Faculty of Tropical Medicine, Mahidol University (TMEC 16-042). CONSENT FOR 
      PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they 
      have no competing interest. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2017/07/19 06:00
MHDA- 2018/05/25 06:00
PMCR- 2017/07/17
CRDT- 2017/07/19 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/06/29 00:00 [accepted]
PHST- 2017/07/19 06:00 [entrez]
PHST- 2017/07/19 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
PHST- 2017/07/17 00:00 [pmc-release]
AID - 10.1186/s12902-017-0189-z [pii]
AID - 189 [pii]
AID - 10.1186/s12902-017-0189-z [doi]
PST - epublish
SO  - BMC Endocr Disord. 2017 Jul 17;17(1):44. doi: 10.1186/s12902-017-0189-z.