PMID- 28717055
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20181113
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 79
IP  - 8
DP  - 2017 Aug 18
TI  - Incidence of anaphylactic reactions after propofol administration in dogs.
PG  - 1446-1452
LID - 10.1292/jvms.16-0550 [doi]
AB  - Propofol is an anesthetic agent suspended in an emulsion system that includes egg 
      yolk lecithin and soybean oil, because of which, there is concern about the use 
      of propofol in patients allergic to these substances. We examined the association 
      between propofol administration and incidence of adverse events in dogs with 
      allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an 
      allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE 
      group) and 7 dogs with low levels (normal-IgE group) of IgE were selected. 
      Following intravenous administration of propofol, the incidence of anaphylactic 
      reactions and plasma histamine concentrations under general anesthesia maintained 
      with isoflurane throughout surgery were compared between the two groups. The 
      frequency of anaphylactic reactions and plasma histamine concentrations were 
      compared by the chi-square test and Student t-test, respectively. The statistical 
      significance for both tests was set at P<0.05. In the high- and normal-IgE 
      groups, the average frequencies of anaphylactic reactions after propofol 
      administration were 21.4 and 14.3%, and the mean plasma histamine concentrations 
      were 167.9 +/- 94.5 nM and 65.7 +/- 40.3 nM, respectively. Animals of neither groups 
      experienced shock-like symptoms. These results revealed that propofol might be 
      relatively safe, although careful perioperative anesthesia monitoring and standby 
      protocols are required when using propofol in dogs with a history of allergic 
      diseases or high chicken- or soybean-specific IgE levels.
FAU - Onuma, Mamoru
AU  - Onuma M
AD  - Oosagami Animal Clinic, 1-33-3 Laketown, Koshigaya, Saitama 343-0828, Japan.
AD  - Chiba Institute of Science Faculty of Risk and Crisis Management, 15-8 
      Shiomi-cho, Choshi, Chiba 288-0025, Japan.
FAU - Terada, Misao
AU  - Terada M
AD  - Dokkyo Medical University Laboratory Animal Research Center, Kitakobayashi 880, 
      Shimotsugagun Mibumachi, Tochigi 321-0207, Japan.
FAU - Ono, Sadaharu
AU  - Ono S
AD  - Oosagami Animal Clinic, 1-33-3 Laketown, Koshigaya, Saitama 343-0828, Japan.
FAU - Murakami, Akiyoshi
AU  - Murakami A
AD  - Oosagami Animal Clinic, 1-33-3 Laketown, Koshigaya, Saitama 343-0828, Japan.
FAU - Ishida, Tomoko
AU  - Ishida T
AD  - Oosagami Animal Clinic, 1-33-3 Laketown, Koshigaya, Saitama 343-0828, Japan.
FAU - Sano, Tadashi
AU  - Sano T
AD  - Rakuno Gakuen University School of Veterinary Medicine, 582, 
      Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170714
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Lecithins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8001-22-7 (Soybean Oil)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Anaphylaxis/chemically induced/*veterinary
MH  - Anesthesia, General/adverse effects
MH  - Anesthetics, Intravenous
MH  - Animals
MH  - Dog Diseases/*chemically induced
MH  - Dogs
MH  - Egg Hypersensitivity
MH  - Female
MH  - Hypnotics and Sedatives/*adverse effects
MH  - Immunoglobulin E/analysis
MH  - Incidence
MH  - Lecithins/adverse effects
MH  - Male
MH  - Propofol/*adverse effects
MH  - Retrospective Studies
MH  - Soybean Oil/adverse effects
PMC - PMC5573835
OTO - NOTNLM
OT  - anesthesia
OT  - dog
OT  - histamine
OT  - immunoglobulin-E
OT  - propofol-induced anaphylaxis
EDAT- 2017/07/19 06:00
MHDA- 2018/02/15 06:00
PMCR- 2017/08/01
CRDT- 2017/07/19 06:00
PHST- 2017/07/19 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
PHST- 2017/07/19 06:00 [entrez]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 16-0550 [pii]
AID - 10.1292/jvms.16-0550 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2017 Aug 18;79(8):1446-1452. doi: 10.1292/jvms.16-0550. Epub 2017 
      Jul 14.